Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
FGFR1
→
Complex of CD44-FGF2
(increases, CD44/FGF2 Activity)
Evidence: Furthermore, we show these isoforms are preferentially modified with heparan rather than chondroitin sulfate, bind the macrophage-derived growth factors FGF-2, vascular endothelial growth factor, and heparin-binding epidermal growth factor with varying affinities (K(d) 25-330 nM) and in the case of FGF-2, can stimulate productive binding to the high affinity tyrosine kinase FGF receptor 1 (FGFR1).