Gene interactions and pathways from curated databases and text-mining

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CD79A — PIK3R1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Otero et al., J Biol Chem 2001 (Lymphoma, B-Cell) : A prominent feature of CD19 signaling is the binding and activation of phosphoinositide 3-kinase ( P13K ), which accounts for the majority of PI3K activity induced by BCR ligation
Bracke et al., J Leukoc Biol 2000 (Asthma...) : Moreover, inhibition of PI3K in these cells blocked the background and the TNF-alpha induced IgA binding completely
Ingham et al., J Biol Chem 2001 : Moreover, using confocal microscopy, we show that BCR ligation can induce the translocation of Gab1 from the cytosol to the plasma membrane and that this requires the Gab1 PH domain as well as PI3K activity
Granboulan et al., J Biol Chem 2003 : Strikingly, we found using fluorescent probes binding specifically to PI3K products that BCR and Igbeta but not Igalpha induce PI3K activation in endocytic compartments wherein antigen is transported
Glassford et al., Eur J Immunol 2005 : Furthermore, using both p85alpha-null and p110delta-null B cells and inhibitors of PI3K, this study demonstrates for the first time, that BCR cross linking induces cyclin D2 mRNA expression via transcriptional activation of the cyclin D2 promoter and that this transcriptional activation of cyclin D2 requires PI3K activity
Donahue et al., Eur J Immunol 2007 : We used flow cytometry and magnetic cell sorting to examine the requirement for PI3K and mTOR in responses of splenic B cell subsets to BCR and LPS stimulation
Hodson et al., Adv Exp Med Biol 2009 : Although CD40, TLR and cytokines all activate PI3K the BCR seems especially dependent upon PI3K signalling
Xu et al., Immunol Cell Biol 2012 : To understand the mechanisms of PI3K regulation during B-cell activation, we performed a series of biochemical analysis on primary B cells, and found that activity of Src family tyrosine kinases (SFK) is crucial for the activation of PI3K following BCR ligation and this is regulated by the SFK Lyn
Skorski et al., Blood 1995 (Blast Crisis...) : Phosphatidylinositol-3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome positive cells