◀ Back to CD8A
CD86 — CD8A
Pathways - manually collected, often from reviews:
-
NCI Pathway Database TCR signaling in naïve CD8+ T cells:
TCR/CD3/MHC I/CD8 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B)
→
B7 family/CD28 complex (CD28-CD80_CD86)
(modification, collaborate)
Housden et al., Eur J Biochem 2003, Barber et al., Proc Natl Acad Sci U S A 1989, van Oers et al., J Exp Med 1996, Anel et al., Eur J Immunol 1996
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database TCR signaling in naïve CD8+ T cells:
B7 family/CD28 complex (CD28-CD80_CD86)
→
TCR/CD3/MHC I/CD8/LCK complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK)
(modification, activates)
Housden et al., Eur J Biochem 2003, Barber et al., Proc Natl Acad Sci U S A 1989, van Oers et al., J Exp Med 1996, Anel et al., Eur J Immunol 1996
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database TCR signaling in naïve CD8+ T cells:
TCR/CD3/MHC I/CD8 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B)
→
B7 family/CD28 complex (CD28-CD80_CD86)
(transcription, activates)
Curtsinger et al., J Exp Med 2003
Evidence: assay, other species
-
NCI Pathway Database TCR signaling in naïve CD8+ T cells:
B7 family/CD28 complex (CD28-CD80_CD86)
→
TCR/CD3/MHC I/CD8/LCK complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK)
(modification, activates)
Iwashima et al., Science 1994
Evidence: assay, physical interaction
Text-mined interactions from Literome
Barker et al., Cell Immunol 1999
:
The
role of CD80 and
CD86 in enhancing
CD8 ( + ) cell suppression of HIV replication
Sundquist et al., J Immunol 2005
(Mouth Diseases...) :
Although both
CD8alpha+ and CD8alpha- subsets
increase CD86 expression, CD40 was preferentially up-regulated on CD8alpha+ DC, and CD80 was preferentially increased on CD8alpha- DC
Fuse et al., J Virol 2006
:
In the absence of
CD80/CD86 , primary antiviral
CD8 ( + ) T-cell responses and the induction of neutralizing antibodies were severely
impaired
Viaud et al., J Immunother 2011
:
Here, we show that interferon-? is a key cytokine conditioning the dendritic cell to
induce the expression of CD40, CD80,
CD86 , and CD54 on Dex, endowing them with direct and potent peptide dependent
CD8 ( + ) T-cell triggering potential in vitro and in vivo