Gene interactions and pathways from curated databases and text-mining

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CDC42 — MAPK12

Pathways - manually collected, often from reviews:

  • KEGG VEGF signaling pathway: CDC42 → MAPK11/MAPK12/MAPK13/MAPK14 (protein-protein, activation)
  • Reactome Reaction: MAPK12 → CDC42 (indirect_complex)
  • Reactome Reaction: MAPK12 → CDC42 (reaction)

Text-mined interactions from Literome

Philips et al., J Biol Chem 2000 : Surprisingly, the ability of Cdc42 to induce p38 MAPK activity in suspended mouse embryonic fibroblast was impaired
Arozarena et al., J Biol Chem 2000 : Moreover, we show that the potentiating effect of ionomycin on Ras-GRF mediated MAPK stimulation is also regulated by Cdc42
Rul et al., Ann N Y Acad Sci 2002 (MAP Kinase Signaling System) : Here, we describe that the inhibition of Rac1 or Cdc42 signaling leads to MAPK ERK activation via a pathway involving PI(3)K, Akt, Raf, and MEK, but not Ras
Zhong et al., Blood 2003 (MAP Kinase Signaling System) : Rac and Cdc42 , but not Ras or Rho, were responsible for this MAPK/ERK activation ... We conclude from these data that Rac/Cdc42 dependent activation of MAPK/ERK is a critical event in the immediate phagocytic response of PMNs to microbial challenge
Shi et al., J Immunol 2003 (MAP Kinase Signaling System) : Mechanistically, a small GTPase Cdc42 failed to be activated after TR6 pretreatment of human T cells, and further downstream, p38 mitogen activated protein kinase activation, actin polymerization, and pseudopodium formation were all down-regulated in the treated T cells
Stepan et al., Am J Physiol Gastrointest Liver Physiol 2004 : In contrast, G17 stimulated MAPK activation was blocked by > 80 % by dominant negative Ras but not by dominant negative Rho and Cdc42
Szczur et al., Blood 2006 (MAP Kinase Signaling System) : We further suggest that CDC42GAP mediated extracellular signal regulated kinase ( ERK ) activity regulates motility associated with podosome-like structures at the cell leading edge, while CDC42GAP induced p38 ( MAPK ) phosphorylation regulates directed migration by antagonizing filopodia assembly
Yano et al., Circ Res 2007 (Inflammation) : However, DN-RhoA and DN-Cdc42 activated p38 MAPK , but not ERK1/2
Tobe et al., Cell division 2009 : It was found that Swe1 mediated inhibitory tyrosine phosphorylation of Cdc28 during filamentous growth is in part mediated by Ras2 activation of PKA, but not Kss1-MAPK , signaling