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CDC73 — NGF
Text-mined interactions from Literome
Noga et al., Clin Exp Allergy 2003
(Asthma) :
Cell stimulation with
PAF ( 10-8-10-5 M ) after priming with GM-CSF
leads to a dose-dependant release of
NGF and BDNF
Yoshida et al., Brain Res Mol Brain Res 2005
:
We have addressed the
effect of
platelet activating factor (PAF) , one of the mediators of ischemic injury of the brain, on
NGF expression in astrocytes ... After 48-h stimulation, 10 nmol/L
PAF increased the levels of
NGF protein in astrocyte conditioned medium by 1.4-fold ... The
PAF induced stimulation of
NGF expression was further enhanced ( 2.1-fold of the control ) in the cells under hypoxic culture condition ... We conclude that
PAF enhances
NGF gene expression in human astrocytes, and the PAF induced increase in the expression of NGF under hypoxia may benefit the protection of the nervous tissue by promoting neuronal survival
Brodie et al., Neurosci Lett 1995
:
We have examined the
effect of
platelet activating factor (PAF) , which has been associated with various pathological conditions in the central nervous system, on the secretion of
nerve growth factor (NGF) by astrocytes ...
PAF induced a dose dependent increase in
NGF secretion, the maximal increase of 120 % obtained with 50 nM PAF after 48 h of treatment