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CDKN1A — NOTCH2
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Noseda et al., Mol Cell Biol 2004
:
Activated
Notch inhibits mitogen induced upregulation of
p21Cip1 and delays cyclin D-cdk4 mediated Rb phosphorylation ...
Notch dependent repression of
p21Cip1 prevents nuclear localization of cyclin D and cdk4
Rooman et al., Am J Pathol 2006
(Metaplasia) :
Chemical inhibition of
Notch signaling
resulted in increased proliferation and induction of the cell-cycle regulator
p21Cip1
Henning et al., Cell Death Differ 2008
:
Induction of the
p21 ( cip/waf ) gene by activated
Notch was mediated by increased binding of p53 to p53 binding sites in the p21 ( cip/waf ) promoter and was independent of the canonical RBP-J binding site
Heo et al., Growth Factors 2008
:
Moreover, TGF-alpha increased cyclin D/CDK 4 and cyclin E/CDK 2 levels, while decreasing
p21cip1/waf1 and p27kip1, which were
blocked by the inhibition of Akt, mTOR and
Notch
Cui et al., Cancer Res 2013
(Neoplasms) :
The ability of Notch3 to induce senescence and
p21 expression was
dependent on the canonical
Notch singling