Gene interactions and pathways from curated databases and text-mining

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CDKN1A — NOTCH2

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Noseda et al., Mol Cell Biol 2004 : Activated Notch inhibits mitogen induced upregulation of p21Cip1 and delays cyclin D-cdk4 mediated Rb phosphorylation ... Notch dependent repression of p21Cip1 prevents nuclear localization of cyclin D and cdk4
Rooman et al., Am J Pathol 2006 (Metaplasia) : Chemical inhibition of Notch signaling resulted in increased proliferation and induction of the cell-cycle regulator p21Cip1
Henning et al., Cell Death Differ 2008 : Induction of the p21 ( cip/waf ) gene by activated Notch was mediated by increased binding of p53 to p53 binding sites in the p21 ( cip/waf ) promoter and was independent of the canonical RBP-J binding site
Heo et al., Growth Factors 2008 : Moreover, TGF-alpha increased cyclin D/CDK 4 and cyclin E/CDK 2 levels, while decreasing p21cip1/waf1 and p27kip1, which were blocked by the inhibition of Akt, mTOR and Notch
Cui et al., Cancer Res 2013 (Neoplasms) : The ability of Notch3 to induce senescence and p21 expression was dependent on the canonical Notch singling