Gene interactions and pathways from curated databases and text-mining

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CDKN1A — PIK3R1

Text-mined interactions from Literome

Mitsuuchi et al., Cancer Res 2000 (Ovarian Neoplasms) : Experiments with additional ovarian carcinoma cell lines revealed that PI3K is involved in the expression of p21 induced by cisplatin or paclitaxel in OVCAR-10 cells, which have wild-type p53, but not in OVCAR-5 cells, which lack functional p53
Linnemann et al., Virology 2002 : Moreover, PI3K was required to activate the Nef associated p21 activated kinase (PAK)
Gao et al., Am J Physiol Cell Physiol 2004 (Ovarian Neoplasms) : Expression of the cyclin kinase inhibitor p16(INK4a) was induced by the PI3K inhibitor, whereas steady-state levels of p21 ( CIP1/WAF1 ) were decreased in the same experiment
Lu et al., Int J Oncol 2006 (Prostatic Neoplasms) : PI3K-Akt signaling is involved in the regulation of p21 ( WAF/CIP ) expression and androgen independent growth in prostate cancer cells
Pivoriūnas et al., Mol Cell Biochem 2007 (Leukemia) : Here, we report a novel finding that PI 3-K inhibition by LY294002 significantly increases p21WAF1/Cip1 expression in PMA stimulated human leukemia cells NB4 and THP1
Xia et al., J Biol Chem 2007 (Neoplasms) : Collectively, these findings demonstrate that p21 ( RAS ), through its downstream effector PI3K , induces PKCdelta expression and that this increase in PKCdelta activity, acting through Akt, is required for cell survival
Xing et al., American journal of physiology. Renal physiology 2008 : In contrast, PP1 and PI3K inhibition had no effect on cyclin E and p21
Li et al., Biomed Environ Sci 2010 : Activation of PI3K/Akt1 pathway and subsequent negative regulation of p21 ( WAF1/CIP1 ) and p27 ( KIP1 ) expression might be involved in CagA associated carcinogenesis
Yohn et al., BMC urology 2011 (Carcinoma, Transitional Cell...) : Phosphatidylinositol 3'-kinase , mTOR, and glycogen synthase kinase-3ß mediated regulation of p21 in human urothelial carcinoma cells