◀ Back to CTNNB1
CDX1 — CTNNB1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
CDX1 (CDX1)
→
LEF1/beta catenin complex (LEF1-CTNNB1)
(modification, collaborate)
Béland et al., Mol Cell Biol 2004*
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
CDX1 (CDX1)
→
LEF1/beta catenin/CDX1 complex (LEF1-CTNNB1-CDX1)
(modification, collaborate)
Béland et al., Mol Cell Biol 2004*
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
LEF1/beta catenin complex (LEF1-CTNNB1)
→
LEF1/beta catenin/CDX1 complex (LEF1-CTNNB1-CDX1)
(modification, collaborate)
Béland et al., Mol Cell Biol 2004*
Evidence: mutant phenotype, physical interaction, other species
Text-mined interactions from Literome
Domon-Dell et al., FEBS Lett 2002
(Colonic Neoplasms) :
Stimulation of
Cdx1 by oncogenic
beta-catenin/Tcf4 in colon cancer cells ; opposite effect of the CDX2 homeoprotein ... Reciprocally, the paralogue homeobox gene Cdx2 exerts an inhibitory effect on the basal and on the
beta-catenin stimulated activity of the
Cdx1 promoter
Hecht et al., J Biol Chem 2003
:
We found that TCF4E but not LEF1 supported
beta-catenin dependent
activation of the
Cdx1 promoter, whereas LEF1 specifically activated the Siamois promoter
Guo et al., J Biol Chem 2004
(Colonic Neoplasms) :
We report that
Cdx1 or Cdx2 expression does
inhibit beta-catenin/TCF transcriptional activity in colon cancer cells