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CEBPA — JUN

Pathways - manually collected, often from reviews:

• BioCarta keratinocyte differentiation: c/EBP-alpha (CEBPA) → SP1/c-FOS/c-JUN/ETS/c/EBP-alpha complex (SP1-FOS-JUN-ETS2_ETS1-CEBPA) (modification, collaborate)
  
• BioCarta keratinocyte differentiation: c/EBP-alpha (CEBPA) → AP-1 complex (FOS-JUN) (modification, collaborate)
• BioCarta keratinocyte differentiation: SP1 → SP1/c-FOS/c-JUN/ETS/c/EBP-alpha complex (SP1-FOS-JUN-ETS2_ETS1-CEBPA) (modification, collaborate)
  
• BioCarta keratinocyte differentiation: HOXA7 → SP1/c-FOS/c-JUN/ETS/c/EBP-alpha complex (SP1-FOS-JUN-ETS2_ETS1-CEBPA) (modification, inhibits)
  
• BioCarta keratinocyte differentiation: SP1/c-FOS/c-JUN/ETS/c/EBP-alpha complex (SP1-FOS-JUN-ETS2_ETS1-CEBPA) → AP-1 complex (FOS-JUN) (modification, collaborate)
• BioCarta keratinocyte differentiation: SP1/c-FOS/c-JUN/ETS/c/EBP-alpha complex (SP1-FOS-JUN-ETS2_ETS1-CEBPA) → ETS (ETS2/ETS1) (modification, collaborate)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CEBPA — JUN (physical association, affinity chromatography technology) Zada et al., Leukemia 2006
• Gene Ontology Complexes transcription factor complex: transcription factor complex complex (ATF7IP-GSC-GCM1-MAFB-NKX2-1-NKX2-5-RARG-KLF4-FOXF1-FOXF2-FOXE3-LDB1-ZFHX3-GATA6-SNAI3-FOXH1-KAT5-AHR-EYA3-NFATC2-CRX-MED27-HES6-SKI-XRCC6-ARNTL-SUB1-JUN-SOX17-SCX-DMBX1-TCF4-TCF7-PDLIM1-TFEB-LBX1-TRRAP-NAA16-EPAS1-MGA-PTF1A-HOXD12-MEF2B-TFDP3-TFDP1-HDAC2-YY1-SMAD9-CLOCK-ONECUT3-SMAD5-SMAD6-SMAD7-SMAD1-SMAD2-PRKDC-RCOR2-NHLH2-REL-TBX5-ARNTL2-BSX-HOXA10-HOXB13-MED23-PUS1-TAL1-RBL1-RBL2-MINA-HMGA1-BARX2-LEF1-EP300-PMF1-ARID5A-WWTR1-LMO2-LMO4-TP73-ABT1-CDK2-DKFZp686M216-CREG1-CTNNB1-SOX9-HAND2-SOX2-TEAD2-MYOG-TEAD4-CEBPA-GFI1B-MYOD1-ALX1-NPAS4-TFAP2D-FIGLA-ALX4-ETS1-PROP1-ASCL3-HCLS1-MSX1-MSX2-SRA1-AJUBA-MTA2-SIN3A-POU3F2-POU3F1-BEX1-MLXIPL-NR2E3-PBX2-ANKRD1-E2F6-E2F5-E2F4-E2F3-E2F2-E2F1-E2F8-CREBBP-ATF5-ATF4-POU2F3) Kaspar et al., J Biol Chem 1999, Wang et al., J Biol Chem 1999, Nagpal et al., J Biol Chem 1999, Blixt et al., Genes Dev 2000, Carlberg et al., Mol Cell Biol Res Commun 2000, Bae et al., Development 2000, Cairo et al., Hum Mol Genet 2001, Tutter et al., Genes Dev 2001, Willis et al., J Biol Chem 2002, Bayne et al., Mol Hum Reprod 2004, Schubert et al., J Biol Chem 2004, Han et al., J Mol Biol 2005, Rodriguez et al., EMBO J 2005, Han et al., Nucleic Acids Res 2005, Zhang et al., Mol Cell Biol 2007, Wong et al., Cell 2009, Stevens et al., Immunology 2009, Stefanovic et al., J Cell Biol 2009, Skokowa et al., Nat Med 2012, Ge et al., Cell 1994, Durocher et al., EMBO J 1997, Hogenesch et al., Proc Natl Acad Sci U S A 1998, Hellqvist et al., J Biol Chem 1998, Ryu et al., Nature 1999

Text-mined interactions from Literome

Rangatia et al., Mol Cell Biol 2002 : An ectopic increase of C/EBPalpha expression decreases the c-Jun mRNA level, and the human c-Jun promoter activity is downregulated eightfold in the presence of C/EBPalpha ... C/EBPalpha and c-Jun interact through their leucine zipper domains, and this interaction prevents c-Jun from binding to DNA
Liu et al., Blood 2003 : C/EBPalpha-ER strongly inhibited endogenous AP-1 DNA binding
Kim et al., Exp Mol Med 2002 : C/EBP binding activity to site F of the rat GLUT2 glucose transporter gene promoter is attenuated by c-Jun in vitro
Rangatia et al., Oncogene 2003 (Leukemia, Myeloid, Acute) : Elevated c-Jun expression in acute myeloid leukemias inhibits C/EBPalpha DNA binding via leucine zipper domain interaction
Gagliardi et al., J Biol Chem 2003 : C/EBP inhibition enhanced the expression of the three major components of AP-1 in cycling CEF, namely c-Jun, JunD, and Fra-2, and stimulated AP-1 activity
Friedman et al., Blood Cells Mol Dis 2003 : In 32DPKCdelta cells, C/EBPalpha-ER strongly inhibits endogenous or exogenous JunB induction, dependent upon the outer surface of the C/EBPalpha basic region, but does not inhibit c-Jun , PU.1, or C/EBPbeta expression
Hong et al., J Leukoc Biol 2011 : C/EBPa : AP-1 heterodimers bound either site preferentially in a gel-shift assay, C/EBPa : c-Fos ER fusion proteins induced endogenous Fosb mRNA but not in the presence of CHX, C/EBP and AP-1 proteins bound the endogenous Fosb promoter, mutation of the -56 cis element reduced reporter activity fivefold, and endogenous FosB protein was expressed preferentially during monopoiesis versus granulopoiesis
Lee et al., J Cell Biochem 2012 (Insulin Resistance...) : In addition, attempts to elucidate a possible mechanism underlying the artemisinic acid mediated effects revealed that reduced expression of the C/EBP d gene was mediated by inhibiting Jun N-terminal kinase (JNK)