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CER1 — NODAL
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Katoh et al., Int J Mol Med 2006
:
CER1 ( Cerberus 1 ) and GREM3 ( CKTSF1B3 or CER2 )
inhibit NODAL signaling through ACVR1B ( ALK4 ) or ACVR1C ( ALK7 ) to SMAD2 or SMAD3 ...
CER1 upregulation in human ES cells
leads to
Nodal signaling inhibition associated with differentiation of human ES cells
Foley et al., Dev Biol 2007
:
This idea was further supported by the combinatorial effect of morpholino medicated knockdown of Cerberus and Hex, which is required for Dkk1 induced cardiogenesis, and the differential roles of essential downstream effectors :
Nodal pathway activation did not
induce the transcriptional repressor Hex while Dkk-1 did not induce
Cerberus ... These studies demonstrated that cardiogenesis in mesoderm depends on
Nodal mediated induction of
Cerberus in underlying endoderm, and that this pathway functions in a pathway parallel to cardiogenesis initiated through the induction of Hex by Wnt antagonists
Foley et al., Ann N Y Acad Sci 2006
:
We also discuss recent data showing that
Nodal also
acts indirectly through stimulation of the secreted protein
Cerberus , which is a member of the differential screening selected aberrant in neuroblastoma ( DAN ) family of secreted proteins
Yu et al., Dev Dyn 2008
:
In the chick, it was suggested that chick
Cerberus ( cCer ), a Cerberus/Dan family member,
induces Nodal expression by antagonizing bone morphogenetic protein ( BMP ) activity in the left LPM