Gene interactions and pathways from curated databases and text-mining

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CLEC7A — SYK

Pathways - manually collected, often from reviews:

  • KEGG Tuberculosis: Complex of CLEC7A-SRC → SYK (protein-protein, activation)

Text-mined interactions from Literome

Lee et al., Immunol Cell Biol 2012 (Mycobacterium Infections, Nontuberculous) : Dectin-1 dependent Syk signaling, but not that of MyD88, led to the activation of caspase-1 and secretion of IL-1ß through the activation of an NLRP3/apoptosis associated speck-like protein containing a caspase recruitment domain (ASC) inflammasome
Ma et al., J Biol Chem 2012 : Further, Dectin-1 directs the recruitment of LC3II to phagosomes, and this requires Syk , activation of reactive oxygen production by the NADPH oxidase, and ATG5
Mansour et al., J Biol Chem 2013 : Inhibition of Src or Syk results in prolonged retention of GFP-Dectin-1 to the phagosome signifying a link between Syk and intraphagosomal pH ... Phagosomes containing Candida albicans also require Dectin-1 dependent Syk activation for phagosomal maturation ... Taken together, these results support a model where Dectin-1 not only controls internalization of ß-1,3-glucan containing cargo and triggers proinflammatory cytokines, but also acts as a master regulator for subsequent phagolysosomal maturation through Syk activation