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CLEC7A — SYK
Pathways - manually collected, often from reviews:
-
KEGG Tuberculosis:
Complex of CLEC7A-SRC
→
SYK
(protein-protein, activation)
Text-mined interactions from Literome
Lee et al., Immunol Cell Biol 2012
(Mycobacterium Infections, Nontuberculous) :
Dectin-1 dependent
Syk signaling, but not that of MyD88, led to the activation of caspase-1 and secretion of IL-1ß through the activation of an NLRP3/apoptosis associated speck-like protein containing a caspase recruitment domain (ASC) inflammasome
Ma et al., J Biol Chem 2012
:
Further,
Dectin-1 directs the recruitment of LC3II to phagosomes, and this
requires Syk , activation of reactive oxygen production by the NADPH oxidase, and ATG5
Mansour et al., J Biol Chem 2013
:
Inhibition of Src or
Syk results in prolonged retention of
GFP-Dectin-1 to the phagosome signifying a link between Syk and intraphagosomal pH ... Phagosomes containing Candida albicans also require
Dectin-1 dependent
Syk activation for phagosomal maturation ... Taken together, these results support a model where
Dectin-1 not only controls internalization of ß-1,3-glucan containing cargo and triggers proinflammatory cytokines, but also
acts as a master regulator for subsequent phagolysosomal maturation through
Syk activation