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CPOX — GAST

Text-mined interactions from Literome

Brzozowski et al., J Physiol Pharmacol 2000 (Peptic Ulcer) : Rats with gastric ulcers induced by serosal application of acetic acid ( ulcer area 28 mm2 ) received a submucosal injection of either : 1 ) vehicle ( saline ), 2 ) HGF and 3 ) gastrin with or without neutralizing antibodies against HGF and gastrin or treatment with indomethacin ( 2 mg/kg-d i.p. ), a non-specific inhibitor of COX , or NS-398 ( 5 mg/kg-d i.g. ) and Vioxx ( 10 mg/kg-d i.g. ), both highly specific COX-2 inhibitors
Kanda et al., Am J Physiol Gastrointest Liver Physiol 2006 (Hypertrophy...) : Recently, it has been reported that gastrin induces cyclooxygenase-2 (COX-2) in human gastric and colorectal cancer cell lines
Seo et al., Ann N Y Acad Sci 2007 : Cyclooxygenase-2 (COX-2) is induced by inflammatory cytokines, growth factors, gastrin , and reactive oxygen species in gastric epithelial cells, which may lead to mutagenesis and subsequent metaplasia, dysplasia, and cancer formation
Subramaniam et al., Gastroenterology 2008 (Adenocarcinoma...) : Gastrin induces the expression of cyclooxygenase (COX)-2 and interleukin (IL)-8 ; however, the mechanism ( s ), especially in gastric epithelial cells, is not well understood