◀ Back to PIK3R1
CREB1 — PIK3R1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Huang et al., Mol Cell Neurosci 2005
:
Insulin also induced rapid and long-term ( 30 h )
PI 3-K dependent phosphorylation of Akt and cAMP response element binding protein (
CREB )
Maldonado et al., Biochem Biophys Res Commun 2005
(Calcium Signaling) :
IGF-1 induced
CREB phosphorylation was
mediated by MEK1/ERK,
PI3-K , p38-MAPK, as well as Ca ( 2+ ) /calmodulin kinase and calcineurin
Cechin et al., Neurochem Res 2005
(Glioma) :
The LPA induced phosphorylation of ERK 1/2 and
CREB was
blocked by inhibition of
PI3K , PKC and MEK, but that of Akt was only inhibited by wortmannin, the PI3K inhibitor
Wang et al., J Biomed Sci 2007
:
In conclusion, A20 attenuates neointimal formation after arterial injury as well as cell proliferation and migration in response to TNF-alpha in VSMCs through blocking
PI3K/Akt/GSKbeta dependent activation of
CREB
Caravatta et al., J Cell Physiol 2008
(Leukemia...) :
PI3-K/Akt dependent
activation of
cAMP-response element binding ( CREB ) protein in Jurkat T leukemia cells treated with TRAIL
Song et al., Gut 2007
(Adenocarcinoma...) :
Unconjugated bile acids
induce CREB and AP-1 dependent COX-2 expression in Barrett 's oesophagus and OA through ROS mediated activation of
PI3K/AKT and ERK1/2
Kim et al., J Lipid Res 2010
:
The lipogenic effects of GIP in the presence of insulin are therefore at least partially mediated by upregulation of adipocyte LPL gene transcription through a pathway involving
PI3-K/PKB/AMPK dependent
CREB/TORC2 activation
Wang et al., J Immunol 2011
:
IFN-ß increased the phosphorylated levels of
CREB and STAT3 but only CREB levels were
affected by
PI3K
Tang et al., Int J Biochem Cell Biol 2012
:
Therefore, we conclude that
PI3K activated by Epac
leads to the activation of
PKB/CREB signaling and the up-regulation of PPAR? expression, which in turn activate the transcription of adipogenic genes ; whereas osteogenesis is driven by Rho/FAK/MEK/ERK/Runx2 signaling, which can be inhibited by Epac via PI3K
Yano et al., Cell communication and signaling : CCS 2012
:
PI3K/Akt dependent activation of
cAMP responsive element binding protein ( CREB)-1 induced expression of matrix metalloproteinase (MMP)-9 and suppressing MMP activity by doxycycline partially reversed FN accumulation in the InsR silenced cells ...
PI3K/Akt dependent activation of cAMP responsive element binding protein (
CREB)-1 induced expression of matrix metalloproteinase (MMP)-9 and suppressing MMP activity by doxycycline partially reversed FN accumulation in the InsR silenced cells