Gene interactions and pathways from curated databases and text-mining

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CREB5 — PIK3R1

Text-mined interactions from Literome

Huang et al., Mol Cell Neurosci 2005 : Insulin also induced rapid and long-term ( 30 h ) PI 3-K dependent phosphorylation of Akt and cAMP response element binding protein ( CREB )
Maldonado et al., Biochem Biophys Res Commun 2005 (Calcium Signaling) : IGF-1 induced CREB phosphorylation was mediated by MEK1/ERK, PI3-K , p38-MAPK, as well as Ca ( 2+ ) /calmodulin kinase and calcineurin
Cechin et al., Neurochem Res 2005 (Glioma) : The LPA induced phosphorylation of ERK 1/2 and CREB was blocked by inhibition of PI3K , PKC and MEK, but that of Akt was only inhibited by wortmannin, the PI3K inhibitor
Wang et al., J Biomed Sci 2007 : In conclusion, A20 attenuates neointimal formation after arterial injury as well as cell proliferation and migration in response to TNF-alpha in VSMCs through blocking PI3K/Akt/GSKbeta dependent activation of CREB
Caravatta et al., J Cell Physiol 2008 (Leukemia...) : PI3-K/Akt dependent activation of cAMP-response element binding ( CREB ) protein in Jurkat T leukemia cells treated with TRAIL
Song et al., Gut 2007 (Adenocarcinoma...) : Unconjugated bile acids induce CREB and AP-1 dependent COX-2 expression in Barrett 's oesophagus and OA through ROS mediated activation of PI3K/AKT and ERK1/2
Kim et al., J Lipid Res 2010 : The lipogenic effects of GIP in the presence of insulin are therefore at least partially mediated by upregulation of adipocyte LPL gene transcription through a pathway involving PI3-K/PKB/AMPK dependent CREB/TORC2 activation
Wang et al., J Immunol 2011 : IFN-ß increased the phosphorylated levels of CREB and STAT3 but only CREB levels were affected by PI3K
Tang et al., Int J Biochem Cell Biol 2012 : Therefore, we conclude that PI3K activated by Epac leads to the activation of PKB/CREB signaling and the up-regulation of PPAR? expression, which in turn activate the transcription of adipogenic genes ; whereas osteogenesis is driven by Rho/FAK/MEK/ERK/Runx2 signaling, which can be inhibited by Epac via PI3K
Yano et al., Cell communication and signaling : CCS 2012 : PI3K/Akt dependent activation of cAMP responsive element binding protein ( CREB)-1 induced expression of matrix metalloproteinase (MMP)-9 and suppressing MMP activity by doxycycline partially reversed FN accumulation in the InsR silenced cells