Gene interactions and pathways from curated databases and text-mining

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CRK — CSF2

Text-mined interactions from Literome

Bowdish et al., J Immunol 2004 (MAP Kinase Signaling System) : Activation of ERK1/2 and p38 was markedly increased by the presence of GM-CSF , but not M-CSF
Senokuchi et al., J Biol Chem 2005 : GM-CSF induced p38 MAPK phosphorylation was also inhibited by farnesyl transferase inhibitor or geranylgeranyl transferase inhibitor, and farnesyl pyrophosphate and geranylgeranyl pyrophosphate prevented the suppression of GM-CSF induced p38 MAPK phosphorylation by statins
Smith et al., Br J Pharmacol 2006 (Pneumonia) : p38 MAPK may regulate cytokine production, therefore, the effect of two p38 MAPK inhibitors, SB239063 and SD-282, on the release of TNF-alpha, GM-CSF and IL-8 from human macrophages was investigated
Knobloch et al., Thorax 2009 : ET-1- and TNFalpha induced GM-CSF expression were both reduced by bosentan as well as by specific inhibition of either ET ( A ) R, ET ( B ) R, p38 ( MAPK ) or ERK-1/-2
Suzuki et al., Blood 1999 : GM-CSF- or TNF induced superoxide ( O2- ) release was inhibited by p38 MAPK inhibitor ( SB203580 ) in a dose dependent manner, suggesting the possible involvement of p38 MAPK in GM-CSF- or TNF induced O2- release