Gene interactions and pathways from curated databases and text-mining

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CRK — PIK3R1

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Take et al., Biochem Biophys Res Commun 2000 : Our results suggest that CIN85 may play a specific role in the EGF receptor mediated signaling cascade via its interaction with c-Cbl
Petrelli et al., Nature 2002 : Cbl, in turn, binds and ubiquitinates activated HGF receptor , and by recruiting the endophilin-CIN85 complex , it regulates receptor internalization
Iijima et al., Circulation 2002 : To elucidate the signaling mechanism underlying the RWP effects, we investigated the effects of RWPs on the activity of PI3K and the phosphorylation of MAPK pathways in PDGF-BB stimulated SMCs. RWPs inhibited the PI3K activity and p38 ( MAPK ) phosphorylation, but not ERK1/2 phosphorylation, in a concentration dependent manner
Kowanetz et al., J Biol Chem 2003 : Identification of a novel proline-arginine motif involved in CIN85 dependent clustering of Cbl and down-regulation of epidermal growth factor receptors
Strassheim et al., J Immunol 2004 (Inflammation) : Inhibition of PI3-K also prevented activation of p38 mitogen activated protein kinase and extracellular receptor activated kinase 1/2 in TLR2 stimulated neutrophils
Badr et al., J Immunol 2005 (HIV Infections) : Unlike CXCL12, gp120 did not induce the activation of phospholipase Cbeta3 and PI3K downstream from CXCR4, whereas p38 MAPK activation was observed
Park et al., Toxicol Appl Pharmacol 2006 (Lymphoma) : In contrast, the enhanced AP-1 DNA binding activities and p38 MAPK phosphorylation were significantly suppressed by specific inhibitors for PKC and p38 MAPK, but not by PI3-K inhibitors
Hagiwara et al., Nephrol Dial Transplant 2006 (Diabetes Mellitus, Type 2...) : EPA and specific inhibitors of ERK1/2, JNK and PI3K decreased levels of MCP-1 in MMCs. EPA suppressed phosphorylation of ERK1/2 and p38 in MMCs, and decreased p-ERK positive cells in glomeruli of KKAy/Ta mice
Peruzzi et al., J Immunol 2007 (Calcium Signaling) : We found that CIN85 overexpression inhibits the FcepsilonRI induced tyrosine phosphorylation of phospholipase Cgamma , thus altering calcium mobilization ... Altogether, our findings support a new role for CIN85 in regulating Syk protein levels in RBL-2H3 cells through the activation of the ubiquitin-proteasome pathway and provide a mechanism for this regulation involving c-Cbl ligase activity
Bouchard et al., Apoptosis 2008 : Hence, beta1 integrin/Fak/Src signaling translates into integrated mediating functions of p38beta activation and regulation of Bcl-2 homologs by PI3-K/Akt-1 and MEK/Erk, consequently determining their requirement ( or not ) for survival
Wadhone et al., J Immunol 2009 (Leishmaniasis, Visceral) : Miltefosine induced protein kinase C-dependent and PI3K dependent p38MAP kinase phosphorylation and anti-leishmanial function
Wakasaki et al., Neoplasia (New York, N.Y.) 2010 (Carcinoma, Squamous Cell...) : Little is known, however, about a role of CIN85 in EGFR signaling as well as its relevance to tumor development and progression of HNSCC
Bros et al., Gene 2011 : Both Cacnb3 isoforms, similar to Fscn1, required JNK and p38 kinase activity for stimulation associated upregulation, and this process was inhibited by ERK and PI(3)K
Marois et al., J Biol Chem 2011 : Silencing the expression of CIN85 by siRNA in dibutyryl cyclic AMP differentiated PLB 985 cells prevented Fc?RIIa degradation and increased IgG mediated phagocytosis
Wang et al., J Cell Mol Med 2012 (Carcinoma, Hepatocellular...) : Tumour necrosis factor-a (TNF-a) significantly induced phosphorylation of p38 MAPK, ERK, Akt and production of IL-8 from HCC cells, which were prevented by SB203580 ( p38 MAPK inhibitor ), PD98059 ( ERK inhibitor ), LY294002 and Wortmannin ( PI3K inhibitor ) and SB328437 ( CCR3 inhibitor )
Tossidou et al., Mol Cell Biol 2012 : Our results indicate a novel role for CD2AP in regulating posttranslational modification of CIN85
Yang et al., Biosci Rep 2012 (Insulin Resistance) : In contrast, saturated fatty acid exposure caused insulin resistance, reducing PI3K ( phosphoinositide 3-kinase ) and ERK ( extracellular-signal regulated kinase ) activation while increasing activation of stress kinases JNK ( c-Jun N-terminal kinase ) and p38
Samoylenko et al., Carcinogenesis 2012 (Adenocarcinoma...) : Thereby, Ruk ( l ) /CIN85 led to a more rapid and prolonged epidermal growth factor dependent activation of Src , Akt and ERK1/2 and treatment with the Src inhibitor PP2 and the PI3K inhibitor LY294002 abolished the Ruk ( l ) /CIN85 dependent changes in cell motility ... Thereby, Ruk ( l ) /CIN85 led to a more rapid and prolonged epidermal growth factor dependent activation of Src, Akt and ERK1/2 and treatment with the Src inhibitor PP2 and the PI3K inhibitor LY294002 abolished the Ruk ( l ) /CIN85 dependent changes in cell motility ... Thereby, Ruk ( l ) /CIN85 led to a more rapid and prolonged epidermal growth factor dependent activation of Src, Akt and ERK1/2 and treatment with the Src inhibitor PP2 and the PI3K inhibitor LY294002 abolished the Ruk ( l ) /CIN85 dependent changes in cell motility
Schroeder et al., Mol Biol Cell 2012 : In this study we show that EGFR activation leads to a pronounced src mediated tyrosine phosphorylation of CIN85 that subsequently influences EGFR ubiquitination
Bior et al., FEBS Lett 2013 : Dab1 stabilizes its interaction with Cin85 by suppressing Cin85 phosphorylation at serine 587 ... Furthermore a Cin85 Ser587 phosphomimetic disrupts the Dab1-Cin85 complex without affecting the Cin85-CapZ complex
Fuchigami et al., Genes Cells 2013 : We reported previously that Cdk5-p35 phosphorylates Dab1 at Ser400 and Ser491 and the phosphorylation regulates its binding to CIN85 , which is an SH3 containing multiadaptor protein involved in endocytic downregulation of receptor-tyrosine kinases ... We reported previously that Cdk5-p35 phosphorylates Dab1 at Ser400 and Ser491 and the phosphorylation regulates its binding to CIN85 , which is an SH3 containing multiadaptor protein involved in endocytic downregulation of receptor-tyrosine kinases ... We reported previously that Cdk5-p35 phosphorylates Dab1 at Ser400 and Ser491 and the phosphorylation regulates its binding to CIN85 , which is an SH3 containing multiadaptor protein involved in endocytic downregulation of receptor-tyrosine kinases