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CRP — MMP8

Text-mined interactions from Literome

Montero et al., J Am Coll Cardiol 2006 (Atherosclerosis...) : We examined the effect of C-reactive protein (CRP) on matrix metalloproteinase ( MMP ) and inhibitor expression in endothelial cells and in patients with clinical and subclinical atherosclerosis ... C-reactive protein stimulation also increased MMP-1 and -10 protein in conditioned culture medium ( p < 0.001 ), as well as MMP activity ( p = 0.001 ). Specific inhibition of p38 or MEK abolished the CRP induction of the MMP-1, whereas MMP-10 induction blockade required the simultaneous inhibition of p38 and Jun N-terminal kinase pathways. Subjects with CRP values > 3 mg/l ( n = 37 ) had increased plasma MMP-1 and -10 ( p < 0.05 ), the association being significant after adjustment for confounding variables ( p = 0.04 and p = 0.008, respectively )
Singh et al., J Lipid Res 2008 (Inflammation) : CRP promotes OxLDL uptake and MMP induction in vitro ; however, these have not been investigated in vivo