Gene interactions and pathways from curated databases and text-mining

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CSF1 — PIK3R1

Text-mined interactions from Literome

Kelley et al., J Biol Chem 1999 : In normal human monocytes, M-CSF increased the levels of tyrosine phosphorylated proteins and induced Akt activation in a PI3K dependent manner
Grey et al., Endocrinology 2000 : Taken together, the current data suggest that c-src, via its SH3 domain, may participate in CSF-1 induced activation of PI3-K and that PI3-K and c-src are in the signaling pathway that subserves CSF-1 induced cytoskeletal changes in osteoclasts
Palacio et al., Eur J Endocrinol 2001 : In murine osteoclast-like cells grown from bone marrow cells co-cultured with osteoblasts, the activation of the PI 3-K by CSF-1 was determined both in vivo and in vitro ... In osteoclast-like cells, CSF-1 stimulated PI 3-K activity
Mandal et al., Endocrinology 2009 : Inhibition of PI3K/Akt signaling blocked the binding of Smads 1/5 to the CSF-1 BMP-responsive element present in the CSF-1 promoter, resulting in attenuation of Smad dependent CSF-1 transcription ... Together, these data for the first time demonstrate that PI3K dependent Akt activation regulates BMP-2 induced CSF-1 expression and provides a mechanism for osteoblastic cell assisted osteoclast differentiation