Gene interactions and pathways from curated databases and text-mining

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CSF3 — CSF3R

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: Complex of CSF3R-IL6ST → CSF3 (increases) Kim et al., Mol Cell Biol 1999
    Evidence: HepG2 cells were transfected with expression vector for G-gp130 (WT) and Myc SHP-2CS or SHP-2-Myc and then were treated for 15 minutes with G-CSF, showed that gp130-recruited SHP-2 serves as a major mediator to the ERK pathway and that this function requires the carboxy-terminal half but not the phosphatase activity of the SHP-2 protein.
  • KEGG Cytokine-cytokine receptor interaction: CSF3 → CSF3R (protein-protein, activation)
  • WikiPathways Focal Adhesion-PI3K-Akt-mTOR-signaling pathway: CSF3/EPO/IFNA7/CSH1/IFNA7/IFNA7/IFNA7/IFNA7/IFNA7/IFNA7/IFNA7/IFNA7/IFNB1/IL2/OSM/PRL/IFNA7/IFNA7 → IL3RA/IL2RB/IFNAR1/OSMR/PRLR/IL7R/IL6R/CSF3R/IL2RA/EPOR/IL4R/IL2RG/IFNAR2/GHR (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Inukai et al., Leukemia 2000 (Blast Crisis...) : Unexpectedly, ` myeloid ' cell lines showed lower G-CSFR expression and lower G-CSF response compared with ` biphenotypic ' cell lines
Hörtner et al., J Immunol 2002 : G-CSF regulates granulopoiesis and acts on its target cells by inducing homodimerization of the G-CSFR , thereby activating intracellular signaling cascades
Schuster et al., Blood 2003 : In 32Dcl3 cells transfected with the bcr-abl gene ( 32D ( Bcr-Abl ) ), G-CSF did not trigger either granulocytic differentiation or the up-regulation of C/EBPalpha, C/EBPepsilon, and the G-CSFR
Harada et al., Nat Med 2005 (Myocardial Infarction...) : G-CSF receptor was expressed on cardiomyocytes and G-CSF activated the Jak/Stat pathway in cardiomyocytes
Schneider et al., J Clin Invest 2005 (Brain Ischemia...) : Surprisingly, the G-CSF receptor was also expressed by adult neural stem cells, and G-CSF induced neuronal differentiation in vitro
McCracken et al., J Endocrinol 1996 : These data suggested that expression of G-CSFR in the human placenta is regulated both temporally and spatially, and that placental G-CSF is involved in paracrine regulation, and indicate a role for G-CSF and G-CSFR in trophoblast growth or function during placentation
Asano et al., Cancer Res 1997 (Blast Crisis...) : First, we found that this chimeric soluble G-CSF receptor could inhibit the biological activity of G-CSF on normal bone marrow colony formation