Gene interactions and pathways from curated databases and text-mining

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CSK — PTPN11

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Cunnick et al., J Biol Chem 2002 (MAP Kinase Signaling System) : Mek1 activation by Gab1PH-SHP2DeltaN was inhibited by an Src inhibitor and by Csk
Zhang et al., Mol Cell 2004 : Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment
Kusano et al., Endothelium : journal of endothelial cell research 2008 : To see if tyrosine kinases other than Src are also capable of phosphorylating PZR, the authors cotransfected HEK293 cells with PZR and one of several tyrosine kinases and found that c-Src, c-Fyn, c-Lyn, Csk , and c-Abl, but not c-Fes, phosphorylated PZR and increased PZR/SHP-2 interaction