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CSRP1 — IL10
Text-mined interactions from Literome
Szalai et al., J Immunol 2002
(Encephalomyelitis, Autoimmune, Experimental) :
Human CRP has three effects on cultured encephalitogenic cells that could contribute to the protective effect observed in vivo : 1 )
CRP inhibits encephalitogenic peptide induced proliferation of T cells ; 2 ) CRP inhibits production of inflammatory cytokines ( TNF-alpha, IFN-gamma ) and chemokines ( macrophage-inflammatory protein-1alpha, RANTES, monocyte chemoattractant protein-1 ) ; and 3 ) CRP
increases IL-10 production
Mold et al., J Immunol 2002
:
In vitro, in the presence of LPS,
CRP enhanced
IL-10 synthesis and inhibited IL-12 synthesis by bone marrow macrophages from normal, but not gamma-chain-deficient mice