Gene interactions and pathways from curated databases and text-mining

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CSRP1 — IL10

Text-mined interactions from Literome

Szalai et al., J Immunol 2002 (Encephalomyelitis, Autoimmune, Experimental) : Human CRP has three effects on cultured encephalitogenic cells that could contribute to the protective effect observed in vivo : 1 ) CRP inhibits encephalitogenic peptide induced proliferation of T cells ; 2 ) CRP inhibits production of inflammatory cytokines ( TNF-alpha, IFN-gamma ) and chemokines ( macrophage-inflammatory protein-1alpha, RANTES, monocyte chemoattractant protein-1 ) ; and 3 ) CRP increases IL-10 production
Mold et al., J Immunol 2002 : In vitro, in the presence of LPS, CRP enhanced IL-10 synthesis and inhibited IL-12 synthesis by bone marrow macrophages from normal, but not gamma-chain-deficient mice