Gene interactions and pathways from curated databases and text-mining

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CTNNB1 — NOTCH2

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

  • IRef Intact Interaction: Complex of 50 proteins (colocalization, proximity-dependent biotin identification)
  • IRef Intact Interaction: Complex of 74 proteins (colocalization, proximity-dependent biotin identification)

Text-mined interactions from Literome

Estrach et al., Development 2006 : beta-catenin stimulates Notch signalling by inducing Jag1 transcription
Shi et al., J Biol Chem 2010 : Inhibition of Notch signaling, which has previously been shown to induce bHLH transcription factor expression, increased beta-catenin expression in progenitor cells of the nervous system
Corada et al., Dev Cell 2010 : Both in vivo and in vitro data show that beta-catenin upregulates Dll4 transcription and strongly increases Notch signaling in the endothelium, leading to functional and morphological alterations