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Smith et al., Apoptosis 2003
(Cachexia) :
At least part of the increase in caspase activity may be related to the increased proteasome proteolytic activity, since a
caspase-3 inhibitor completely
attenuated the PIF induced increase in
'chymotrypsin-like ' enzyme activity, the predominant proteolytic activity of the proteasome
Chen et al., In Vivo 2004
:
We report that the extracts of apple and grape are more potent than onion, tomato and celery in : ( i ) inhibiting the proteasomal
chymotrypsin-like activity in leukemia Jurkat T cell extract ; ( ii ) accumulating the polyubiquitinated proteins in intact Jurkat T cells ; ( iii )
inducing activation of
caspase-3/-7 and cleavage of poly ( ADP-ribose ) polymerase in intact Jurkat T cells ; and ( iv ) inducing the appearance of spherical cells preferentially in prostate cancer PC-3 over the normal NIH 3T3 cell line