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CUL1 — SHC1
Text-mined interactions from Literome
O'Farrell et al., Blood 1996
:
In B6M cells, both IL-3 and
SCF stimulate phosphorylation of
Shc and activation of the Ras, Raf-1, MAPK pathway
Jacobs-Helber et al., J Biol Chem 1997
(Leukemia, Erythroblastic, Acute) :
SCF induced proliferation,
SHC phosphorylation, and activation of ERK-1 but did not activate the JAK/STAT pathway ... SCF stimulated SHC phosphorylation and ERK-1 activation independent of the EPOR in cells where the EPOR was down-regulated ; the presence of the EPOR appeared to facilitate
SCF activation of
SHC and ERK-1