Gene interactions and pathways from curated databases and text-mining

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CUL1 — SHC1

Text-mined interactions from Literome

O'Farrell et al., Blood 1996 : In B6M cells, both IL-3 and SCF stimulate phosphorylation of Shc and activation of the Ras, Raf-1, MAPK pathway
Jacobs-Helber et al., J Biol Chem 1997 (Leukemia, Erythroblastic, Acute) : SCF induced proliferation, SHC phosphorylation, and activation of ERK-1 but did not activate the JAK/STAT pathway ... SCF stimulated SHC phosphorylation and ERK-1 activation independent of the EPOR in cells where the EPOR was down-regulated ; the presence of the EPOR appeared to facilitate SCF activation of SHC and ERK-1