Gene interactions and pathways from curated databases and text-mining

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CXADR — MAPK14

Text-mined interactions from Literome

Tfelt-Hansen et al., Endocrinology 2004 (Hypercalcemia...) : Taken together, our data show that activation of PI3K and p38 MAPK but not of MEK1/ERK by the CaR promotes proliferation of H-500 cells as well as affords protection against apoptosis
Ye et al., J Neurosci Res 2004 : The effect of high Ca2+ ( o ) on p38 MAPK but not ERK1/2 is CaR mediated , insofar as transduction with a dominant negative CaR ( R185Q ) using recombinant adeno associated virus ( rAAV ) attenuated the activation of p38 MAPK but not of ERK1/2 ... p38 MAPK activation by the CaR is likely to be protein kinase C ( PKC ) independent, in that the pan-PKC inhibitor GF109203X failed to abolish the high-Ca2+ ( o ) -induced phosphorylation of p38 MAPK
Gray et al., J Endocrinol 2006 : CaR activation was also associated with an activation of p42/44 mitogen activated protein kinases ( MAPK ), and CaR induced insulin secretion was reduced by an inhibitor of p42/44 MAPK activation