Peng et al., Glia 2006
(AIDS Dementia Complex...) :
The MCM induced production of SDF-1 was prevented by IL-1beta receptor antagonist (IL-1Ra) and IL-1beta siRNA treatment of human MDM. These laboratory observations were confirmed in severe combined immunodeficient ( SCID ) mice with HIV-1 encephalitis ( HIVE )
Marriott et al., Infect Immun 2012
(Pneumococcal Infections) :
Interleukin-1Ra (IL-1Ra) inhibits CXCL8 release from cocultures and reduces the activity of macrophage conditioned media, but inhibition of tumor necrosis factor alpha ( TNF-a ) had only a minimal effect on CXCL8 release