Gene interactions and pathways from curated databases and text-mining

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CXCL12 — PIK3R1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Hwang et al., Int J Hematol 2006 : IFN-gamma did not enhance SDF-1 induced activation of PI3K/Akt or up-regulate the expression of CXCR4 or its function in bone marrow CD34+ cells
Smith et al., Cell Signal 2007 : Use of second generation inhibitors that can discriminate between individual PI3K isoforms, revealed that PI3Kgamma was the major contributor to CXCL12 induced migration and PI3K/Akt signaling ( as assessed by S6 phosphorylation )
Lin et al., J Biol Chem 2011 : Thrombin induced IL-8/CXCL8 release and IL-8/CXCL8-luciferase activity were attenuated by a PI3K inhibitor ( LY294002 ), an Akt inhibitor ( 1-L-6-hydroxymethyl-chiro-inositol-2- ( ( R ) -2-O-methyl-3-O-octadecylcarbonate ) ), and the dominant negative mutants of Rac1 ( RacN17 ) and Akt ( AktDN )
Wang et al., World J Gastroenterol 2011 (Colonic Neoplasms) : SDF-1 induced significant phosphorylation of PI3K/AKT and ß-catenin
Chen et al., J Biol Chem 2012 (Stomach Neoplasms) : Moreover, CXCR4 immunoprecipitated by anti-p110ß antibody increased after CXCL12 stimulation and G ( i ) protein inhibitor pertussis toxin abrogated CXCL12 induced activation of PI3K
Li et al., Am J Transplant 2012 (Arteriosclerosis) : Conditioned media from Ltv-p53 transferred SMCs activated PI3K/Akt/mTOR and MAPK/Erk signaling in a SDF-1a dependent manner and thereby promoted mesenchymal stem cell (MSC) migration and proliferation