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CXCL12 — WNT6

Text-mined interactions from Literome

Liu et al., Diabetologia 2009 : Since AKT is known to modulate the wingless-type MMTV integration site family ( WNT ) signalling cascade, we examined the effects of SDF-1/CXCR4 on WNT signalling in beta cells and whether this signalling is important for cell survival ... Activation of downstream WNT signalling ( beta-catenin and transcription factor 7-like 2, [ TCF7L2 ] ) in response to SDF-1 was examined in the islets of WNT signalling reporter ( Tcf-optimal promoter beta-galactosidase ) mice and in INS-1 and MIN6 beta cells ... SDF-1 induced WNT signalling in beta cells of isolated islets and in INS-1 cells via CXCR4 mediated activation of Galphai/o coupled signalling and the phosphatidylinositol 3-kinase/AKT signalling cascade resulting in the inhibition of glycogen synthase kinase 3-beta ... The key WNT signalling regulators, beta-catenin and AKT, were activated by SDF-1 at the transcriptional and post-translational levels
Zheng et al., Hematology 2011 (Leukemia...) : Moreover, SDF-1a increased the expression of Wnt/beta-catenin target genes, including beta-catenin, cyclin-D1, and c-myc ; however, this manner was abolished by blockage with the hERG1 K ( + ) channels
Choe et al., Dev Neurosci 2012 : This suggests that Wnt activation of dentate gyrus progenitors induces Cxcl12 signaling by regulating receptor expression