Gene interactions and pathways from curated databases and text-mining

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CXCL16 — SRC

Text-mined interactions from Literome

Chandrasekar et al., J Biol Chem 2005 : Src kinase inhibitors PP1 and PP2, phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY294002, Akt inhibitor, the c-Jun N-terminal kinase (JNK) inhibitor SP600125, antisense JNK and dominant negative MyD88, interleukin-1 receptor associated kinase ( IRAK)-1, IRAK4, and phosphatidylinositol 3-kinase expression all attenuated IL-18 mediated AP-1 binding and reporter activity, CXCL16 promoter-reporter activity, and CXCL16 expression
Lin et al., J Immunol 2006 : Thrombin induced increase in IL-8/CXCL8-Luc activity was inhibited by the dominant negative mutant of c-Src and the cells transfected with the kappaB site mutation of the IL-8/CXCL8 construct
Petrai et al., Int J Biochem Cell Biol 2008 : In cells expressing CXCR3-A, CXCL10 ( IP-10 ) at nanomolar concentrations induced activation of ERK, Akt, and Src , as previously described in human vascular pericytes