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CXCR4 — PIK3R1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Janas et al., J Exp Med 2010
:
These findings establish a role for
CXCR4 mediated
PI3K signaling that, together with signals from Notch and the preTCR, contributes to continued T cell development beyond beta-selection
Janas et al., J Immunol 2011
:
Mice with a mutant allele of p110? unable to bind active Ras revealed that
CXCR4 mediated
PI3K activation is Ras dependent
Heskamp et al., Neurobiol Dis 2013
(Disease Models, Animal...) :
Furthermore, the neurite growth promoting and disinhibitory effects of CXCL12 were abrogated by a specific
CXCR4 antagonist and by
inhibition of the
PI3K/AKT/mTOR- , but not the JAK/STAT3-pathway