Gene interactions and pathways from curated databases and text-mining

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CXCR4 — PIK3R1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Janas et al., J Exp Med 2010 : These findings establish a role for CXCR4 mediated PI3K signaling that, together with signals from Notch and the preTCR, contributes to continued T cell development beyond beta-selection
Janas et al., J Immunol 2011 : Mice with a mutant allele of p110? unable to bind active Ras revealed that CXCR4 mediated PI3K activation is Ras dependent
Heskamp et al., Neurobiol Dis 2013 (Disease Models, Animal...) : Furthermore, the neurite growth promoting and disinhibitory effects of CXCL12 were abrogated by a specific CXCR4 antagonist and by inhibition of the PI3K/AKT/mTOR- , but not the JAK/STAT3-pathway