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CYP19A1 — MAPK8
Text-mined interactions from Literome
Shozu et al., J Steroid Biochem Mol Biol 2001
:
We examined the
role of
MAPK on
aromatase activity using PD98059, a selective inhibitor of MEK-1 ... These results indicated that
MAPK plays an important role in
aromatase activation at the post-transcriptional level
Catalano et al., J Biol Chem 2003
(Breast Neoplasms) :
In the
presence of either
mitogen activated protein kinase inhibitor PD 98059 or ERK2 dominant negative as well as in the presence of STAT3 dominant negative, the stimulatory effects of leptin on
aromatase promoter, enzymatic activity, and aromatase protein content were inhibited
Yue et al., J Steroid Biochem Mol Biol 2003
(Breast Neoplasms...) :
In aromatase over expressing MCF-7 cells,
aromatase activity was
reduced by inhibitors of
MAPK and PI3K suggesting the involvement of protein phosphorylation in the regulation of aromatase activity
Sabnis et al., Cancer Res 2008
(Breast Neoplasms...) :
The expression of phosphorylated
mitogen activated protein kinase ( MAPK ) was reduced and ERalpha and
aromatase levels
increased compared with LTLT-Ca cells and were similar to levels in MCF-7Ca cells
Su et al., J Steroid Biochem Mol Biol 2011
(Breast Neoplasms) :
Our study reveals that PI3K/Akt and
MAPK inhibitors
suppressed aromatase activity in MCF-7aro cells
Chen et al., Mol Endocrinol 2011
(Breast Neoplasms) :
The
c-Jun N-terminal kinase 1 and p38a mitogen activated protein kinases are
necessary for PGE ( 2 ) activation of
aromatase promoters I.3/II ; thus, we examined the roles of downstream targets, c-Jun, JunB, JunD, and activating transcription factor 2, in PGE ( 2 ) -mediated regulation of aromatase expression in BAF
Ghosh et al., Nature communications 2013
:
This mechanical cue is transduced sequentially by discoidin domain receptor 1,
c-Jun N-terminal kinase 1 , and phosphorylated JunB, which binds to and
activates two breast cancer associated
aromatase promoters