Gene interactions and pathways from curated databases and text-mining

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CYP19A1 — TNF

Text-mined interactions from Literome

Purohit et al., Biochem Biophys Res Commun 1999 : Inhibition of tumor necrosis factor alpha stimulated aromatase activity by microtubule stabilizing agents, paclitaxel and 2-methoxyestradiol ... In this study, we have examined the ability of paclitaxel or 2-meOE2 to antagonise TNFalpha stimulated aromatase activity in stromal fibroblasts derived from normal or malignant breast tissues ... Paclitaxel inhibited basal and TNFalpha stimulated aromatase activities by 88 % and 91 % respectively ... 2-MeOE2 also reduced basal and TNFalpha stimulated aromatase activities by 46 % and 56 % respectively ... The 16alpha hydroxylated derivative of 2-meoE2 and 2-meOE3, which does not bind to microtubules, was less effective at inhibiting TNFalpha stimulated aromatase activity
Singh et al., Endocr Relat Cancer 1999 (Breast Neoplasms) : PGE2, TNFalpha and IL-6 plus its soluble receptor (IL-6sR) all increased aromatase activity in these cells
Purohit et al., Breast Cancer Res 2002 (Breast Neoplasms) : The activities of the aromatase , estradiol 17beta-hydroxysteroid dehydrogenase and estrone sulfatase are all increased by IL-6 and TNF-alpha
Bourguiba et al., J Steroid Biochem Mol Biol 2003 : Therefore in germ cells TNFalpha likely enhances expression of aromatase through promoter PI.4 in PS, possibly via an AP1 site upstream the GAS element, while in RS TNFalpha requires glucocorticoids as a co-stimulator to increase CYP19 gene expression
Carreau et al., Reprod Biol 2004 : In contrast, tumor necrosis factor alpha (TNFalpha) stimulated Cyp19 expression in pachytene spermatocytes ... Therefore, we suggest that in germ cells, TNFalpha enhances expression of aromatase through promoter PI.4 in pachytene spermatocytes, possibly via an AP1 site upstream the GAS element, while in round spermatids TNF requires glucocorticoids as a co-stimulator to increase Cyp19 gene expression
Velasco et al., Mol Hum Reprod 2006 (Endometriosis) : The aims of this study were, on the one hand, to determine the presence of aromatase in eutopic and ectopic endometrium, healthy peritoneum, myometrium and leiomyomas from patients with ( n = 61 ) and without endometriosis ( n = 12 ) and, on the other hand, to determine the effect of peritoneal fluid ( PF ), interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNFalpha) on aromatase activity from endometriotic stromal cells and subcutaneous adipocytes
Emoto et al., Proc Soc Exp Biol Med 1991 : Although basic fibroblast growth factor ( 1-100 ng/ml ), acidic fibroblast growth factor ( 1 ng/ml ), epidermal growth factor ( 1 ng/ml ), platelet derived growth factor ( 1 ng/ml ), tumor necrosis factor ( 1 ng/ml ), and transforming growth factor-beta 1 ( 1 ng/ml ) have no effect on basal aromatase activity in human skin fibroblasts, all of these growth factors inhibited the ability of dibutyryladenosine 3',5'-cyclic monophosphate to stimulate aromatase activity
Cutolo et al., Ann N Y Acad Sci 2006 (Autoimmune Diseases) : Abnormal regulation of aromatase activity ( i.e., increased activity ) by inflammatory cytokine production ( i.e., TNF-alpha , IL-1, and IL-6 ) may partially explain the abnormalities of peripheral estrogen synthesis in RA ( i.e., increased availability of 17-beta estradiol and possible metabolites in synovial fluids ) and in systemic lupus erythematosus, as well as the altered serum sex-hormone levels and ratio ( i.e., decreased androgens and DHEAS )
Salama et al., PloS one 2009 (Leiomyoma...) : In addition, COMT over expression or treatment with 2ME reduced the expression of hypoxia-inducible factor -1alpha ( HIF-1 alpha ) and the basal level as well as TNF-alpha induced aromatase ( CYP19 ) expression
Nothnick et al., Minerva Ginecol 2010 (Endometriosis) : Potential target areas which may be attractive alternatives to current therapies are also reviewed and include aromatase inhibitors, angiogenesis disruptors and anti-tumor necrosis factor-alpha inhibitors
Hoshino et al., J Med Chem 2010 : Five resveratrol sulfate metabolites were synthesized and assessed for activities known to be mediated by resveratrol : inhibition of tumor necrosis factor (TNF) alpha induced NFkappaB activity, cylcooxygenases ( COX-1 and COX-2 ), aromatase , nitric oxide production in endotoxin stimulated macrophages, proliferation of KB or MCF7 cells, induction of quinone reductase 1 (QR1), accumulation in the sub-G ( 1 ) phase of the cell cycle, and quenching of 2,2-diphenyl-1-picrylhydrazyl ( DPPH ) free radical
Luqman et al., J Med Food 2011 : Suppression of tumor necrosis factor-a induced nuclear factor ?B activation and aromatase activity by capsaicin and its analog capsazepine
Bulun et al., Trends Endocrinol Metab 2012 (Breast Neoplasms...) : In breast adipose fibroblasts, increased TNF production may induce the distal aromatase promoter, whereas increased local PGE ( 2 ) production may induce the proximal promoter region
Emoto et al., Biochem Biophys Res Commun 1988 : The effect of tumor necrosis factor/cachectin on follicle stimulating hormone induced aromatase activity in cultured rat granulosa cells ... We investigated the effects of tumor necrosis factor (TNF)/cachectin on follicle stimulating hormone ( FSH ) -induced aromatase activity in cultured rat granulosa cells using the stereospecific transfer of 3H from [ 1 beta-3H ] androstenedione into 3H2O ... TNF ( 10 pg/ml-10 ng/ml ) inhibited FSH ( 250 ng/ml ) -induced aromatase activity in a concentration dependent manner, and 10 ng/ml of TNF completely abolished the FSH induced aromatase activity ... TNF ( 10 ng/ml ) also inhibited the ability of TGF beta ( 1 ng/ml ) to enhance aromatase activity and increase progesterone synthesis
Wuttke et al., Hum Reprod 1993 : The TNF mediated inhibition of aromatase activity therefore prevents the luteotrophic effects of a variety of peptides including oxytocin
Santana et al., Endocrinology 1995 : Ceramide mediates tumor necrosis factor effects on P450-aromatase activity in cultured granulosa cells
Macdiarmid et al., Mol Cell Endocrinol 1994 (Breast Neoplasms...) : TNF alpha ( 2.5-10.0 ng/ml ), in the presence of stripped fetal calf serum and dexamethasone, significantly stimulated fibroblast aromatase activity in a dose dependent manner
Mauduit et al., Endocrinology 1993 : TNF alpha ( 20 ng/ml ) also inhibited Sertoli cell aromatase activity when stimulated with 8-bromo-cAMP ( 0.01-3 mM, 72 h ) instead of FSH, suggesting that the antigonadotropin action of the cytokine is probably exerted at a step located beyond cAMP formation
Zhao et al., Mol Endocrinol 1996 : Tumor necrosis factor-alpha stimulates aromatase gene expression in human adipose stromal cells through use of an activating protein-1 binding site upstream of promoter 1.4
Noble et al., J Clin Endocrinol Metab 1997 (Endometriosis...) : The effects of interleukin-1 beta (IL-1 beta), IL-2, IL-6, IL-11, oncostatin M, IL-15, tumor necrosis factor-alpha , PGE2, estradiol, R5020, dexamethasone, and dibutyryl cAMP ( Bt2cAMP ) on aromatase activity in endometriosis derived stromal cells were assessed
Shozu et al., Endocrinology 1997 : Previously we have shown that type 1 cytokines as well as tumor necrosis factor-alpha stimulate aromatase activity of adipose stromal cells in the presence of dexamethasone