Gene interactions and pathways from curated databases and text-mining

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CYP7A1 — FGF1

Text-mined interactions from Literome

Kurosu et al., J Biol Chem 2007 : Accordingly, FGF19 , but not FGF21, activates FGF signaling in hepatocytes that primarily express FGFR4 and reduces transcription of CYP7A1 that encodes the rate limiting enzyme for bile acid synthesis
Kim et al., J Lipid Res 2007 : Consistent with these findings, recombinant FGF15 repressed CYP7A1 mRNA levels without affecting CYP8B1 expression
Slätis et al., J Lipid Res 2010 (Atherosclerosis) : The upregulation of Cyp7a1 in DKO mice seemed primarily caused by reduced expression of the intestinal peptide FGF15
Csanaky et al., Hepatology 2011 : Increased expression of fibroblast growth factor 15 in intestines of Oatp1b2-null mice might be responsible for decreased hepatic expression of Cyp7a1 in Oatp1b2-null mice
Kong et al., Hepatology 2012 : However, deficiency of both ERK and JNK pathways prevented Fgf15 mediated suppression of Cyp7a1 and Cyp8b1 gene expression