Gene interactions and pathways from curated databases and text-mining

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CYR61 — MMP1

Text-mined interactions from Literome

Nguyen et al., Cancer Res 2006 (Breast Neoplasms) : Tumor derived Cyr61 ( CCN1 ) promotes stromal matrix metalloproteinase-1 production and protease activated receptor 1-dependent migration of breast cancer cells ... Gene silencing of Cyr61 in breast cancer cells suppresses MMP-1 induction in stromal fibroblasts resulting in a major loss in migration of the cancer cells toward the fibroblasts
Quan et al., Am J Pathol 2006 : In cultured human skin fibroblasts, elevated CYR61 expression substantially reduces type I procollagen and concurrently increases matrix metalloproteinase-1 (MMP-1) , which initiates fibrillar collagen degradation
Chen et al., Regul Toxicol Pharmacol 2011 : MMP-1 mRNA expression is up-regulated by elevated cysteine-rich 61 (CYR61) and monocyte chemoattractant protein-1 ( MCP-1 ) via action of transcription factor AP-1 ... Taken together, CDP inhibits UVB induced MMP-1 expression in skin fibroblasts by suppressing expression of AP-1 and CYR61 and MCP-1 production