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CYR61 — MMP1
Text-mined interactions from Literome
Nguyen et al., Cancer Res 2006
(Breast Neoplasms) :
Tumor derived
Cyr61 ( CCN1 )
promotes stromal
matrix metalloproteinase-1 production and protease activated receptor 1-dependent migration of breast cancer cells ... Gene silencing of
Cyr61 in breast cancer cells
suppresses MMP-1 induction in stromal fibroblasts resulting in a major loss in migration of the cancer cells toward the fibroblasts
Quan et al., Am J Pathol 2006
:
In cultured human skin fibroblasts, elevated
CYR61 expression substantially reduces type I procollagen and concurrently
increases matrix metalloproteinase-1 (MMP-1) , which initiates fibrillar collagen degradation
Chen et al., Regul Toxicol Pharmacol 2011
:
MMP-1 mRNA expression is
up-regulated by elevated
cysteine-rich 61 (CYR61) and monocyte chemoattractant protein-1 ( MCP-1 ) via action of transcription factor AP-1 ... Taken together, CDP
inhibits UVB induced
MMP-1 expression in skin fibroblasts by suppressing expression of AP-1 and
CYR61 and MCP-1 production