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DAB1 — PIK3R1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Reelin signaling pathway:
RELN/VLDLR/DAB1 complex (RELN-VLDLR-DAB1)
→
RELN/VLDLR/DAB1/PI3K complex (RELN-VLDLR-DAB1-PIK3CA-PIK3R1)
(modification, collaborate)
Bock et al., J Biol Chem 2003
Evidence: assay, other species
-
NCI Pathway Database Reelin signaling pathway:
RELN/VLDLR/DAB1 complex (RELN-VLDLR-DAB1)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, collaborate)
Bock et al., J Biol Chem 2003
Evidence: assay, other species
-
NCI Pathway Database Reelin signaling pathway:
RELN/VLDLR/DAB1/PI3K complex (RELN-VLDLR-DAB1-PIK3CA-PIK3R1)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, collaborate)
Bock et al., J Biol Chem 2003
Evidence: assay, other species
-
NCI Pathway Database Reelin signaling pathway:
RELN/VLDLR/DAB1/PI3K complex (RELN-VLDLR-DAB1-PIK3CA-PIK3R1)
→
AKT1 (AKT1)
(modification, activates)
Beffert et al., J Biol Chem 2002
Evidence: assay, other species
Text-mined interactions from Literome
Jossin et al., Mol Cell Biol 2007
:
We show that the mTor ( mammalian target of rapamycin ) -S6K1 ( S6 kinase 1 ) pathway is activated by Reelin and that this depends on
Dab1 ( Disabled-1 ) phosphorylation and
activation of
PI3K and Akt ( protein kinase B )
Yang et al., Proc Natl Acad Sci U S A 2009
:
Thus, we propose that ligation of ApoER2 by APC signals via
Dab1 phosphorylation and subsequent
activation of
PI3K and Akt and inactivation of GSK3beta, thereby contributing to APC 's beneficial effects on cells
Bior et al., FEBS Lett 2013
:
Dab1 stabilizes its interaction with
Cin85 by suppressing Cin85 phosphorylation at serine 587 ... Furthermore a
Cin85 Ser587 phosphomimetic
disrupts the
Dab1-Cin85 complex without affecting the Cin85-CapZ complex
Fuchigami et al., Genes Cells 2013
:
We reported previously that Cdk5-p35 phosphorylates
Dab1 at Ser400 and Ser491 and the phosphorylation
regulates its binding to
CIN85 , which is an SH3 containing multiadaptor protein involved in endocytic downregulation of receptor-tyrosine kinases