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DAB2IP — PIK3R1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Xie et al., Proc Natl Acad Sci U S A 2009
(Prostatic Neoplasms) :
Gain of function study showed that DAB2IP can suppress the PI3K-Akt pathway and enhance ASK1 activation leading to cell apoptosis, whereas loss of
DAB2IP expression
resulted in
PI3K-Akt activation and ASK1-JNK inactivation leading to accelerated PCa growth in vivo
Qiao et al., PloS one 2013
:
Dab2IP regulates
PI3K-AKT signaling and is associated with metastatic prostate cancer, abdominal aortic aneurysms and coronary heart disease