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DDR1 — EDN1
Text-mined interactions from Literome
Piquard et al., J Appl Physiol 2002
:
NEP inhibition
increased circulating
endothelin-1 ( from 2.01 +/- 0.1 to 2.90 +/- 0.2 pmol/l ; P < 0.01 ), atrial natriuretic peptide ( ANP ; from 21.5 +/- 2.7 to 29.6 +/- 3.7 pmol/l ; P < 0.01 ), and the ANP second messenger cGMP
De Lombaert et al., Biochem Biophys Res Commun 1994
:
Unlike CGS 24592, a potent but selective
NEP inhibitor, CGS 26303 significantly
blocks endothelin-1 production in rats after exogenous administration of big ET-1 and reduces the mean arterial pressure in spontaneously hypertensive rats during chronic administration