Gene interactions and pathways from curated databases and text-mining

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DIABLO — PARP8

Text-mined interactions from Literome

Guo et al., Blood 2002 : While it had no activity alone, ectopic overexpression of Smac/DIABLO or treatment with the N-terminus heptapeptide ( Smac-7 ) or tetrapeptide ( Smac-4 ) of Smac/DIABLO significantly increased Epo B- or Apo-2L/TRAIL induced processing and PARP cleavage activity of caspase-3
Colo et al., FEBS Lett 2007 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : In addition to the up-regulation of TRAIL receptors, the process involves Bid, caspases and PARP activation , loss of mitochondrial membrane potential, and release of AIF, cytochrome c and Smac/DIABLO to the cytoplasm