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Brunt et al., Arterioscler Thromb Vasc Biol 2006 : OS was determined by CM-H2DCFDA fluorescence, and apoptosis was assessed by terminal deoxynucleotidyl transferase mediated dUTP nick end labeling ( TUNEL ), caspase-3 activity, and Bcl-2/Bad levels
Cuzzocrea et al., Shock 2008 (Spinal Cord Injuries) : To gain a better insight into the mechanism of action of the anti-inflammatory effects of E2, the following end points of the inflammatory process were evaluated : ( 1 ) spinal cord inflammation and tissue injury ( histological score ) ; ( 2 ) neutrophil infiltration ( myeloperoxidase activity ) ; ( 3 ) expression of iNOS, nitrotyrosine, and COX-2 ; ( 4 ) apoptosis ( terminal deoxynucleotidyltransferase mediated UTP end labeling staining and Bax and Bcl-2 expression ) ; and ( 5 ) tissue TNF-alpha, IL-6, IL-1beta, and monocyte chemoattractant protein 1 levels
Genovese et al., Neuroscience 2007 (Disease Models, Animal...) : Treatment of the mice with etanercept ( 1.25 mg/kg ) and DEX ( 0.025 mg/kg ) when administered as a combination therapy but not as a single treatment significantly reduced the degree of ( 1 ) spinal cord inflammation and tissue injury ( histological score ), ( 2 ) infiltration of neutrophils ( MPO evaluation ), ( 3 ) inducible nitric oxide synthase, nitrotyrosine, and cytokines expression ( tumor necrosis factor-alpha and interleukin-1 beta ), ( 4 ) and apoptosis ( Terminal deoxynucleotidyltransferase mediated UTP end labeling staining, Fas-ligand expression and Bax and Bcl-2 expression )
Genovese et al., Shock 2008 (Disease Models, Animal...) : Thalidomide treatment significantly reduced the degree of : 1 ) spinal cord inflammation and tissue injury ( histological score ) ; 2 ) neutrophil infiltration ( myeloperoxidase evaluation ) ; 3 ) iNOS, nitrotyrosine, lipid peroxidation, and cytokine expression ( TNF-alpha and IL-1beta ) ; 4 ) apoptosis ( terminal deoxynucleotidyltransferase mediated UTP end labeling staining, and Bax and Bcl-2 expression ) ; and 5 ) nuclear factor-kappaB activation
Genovese et al., Shock 2009 (Inflammation...) : Spinal cord injury in mice resulted in severe trauma characterized by edema, tissue damage, and apoptosis ( measured by terminal deoxynucleotidyltransferase mediated dUTP-biotin end labeling staining, Bax, and Bcl-2 expression ) ... In contrast, the degree of ( 1 ) spinal cord inflammation and tissue injury ( histological score ), ( 2 ) nitrotyrosine and poly ( adenosine diphosphate [ ADP ] ribose ) formation, ( 3 ) iNOS expression, ( 4 ) nuclear factor-kappaB activation, and ( 5 ) apoptosis ( terminal deoxynucleotidyltransferase mediated dUTP-biotin end labeling, Bax, and Bcl-2 ) was markedly reduced in spinal cord tissue obtained from mice treated with glycyrrhizin extract ( 10 mg/kg, i.p., 30 min before and 1 and 6 h after SCI )
Paterniti et al., J Neurochem 2010 (Disease Models, Animal...) : Treatment with T0901317, 1 and 6 h after the SCI, significantly decreased ( i ) the degree of spinal cord inflammation and tissue injury ( histological score ) ; ( ii ) neutrophil infiltration ( myeloperoxidase activity ) ; ( iii ) inducible nitric oxide synthase expression ; ( iv ) nitrotyrosine, lipid peroxidation, and poly-ADP-ribose formation ; ( v ) pro-inflammatory cytokines expression ; ( vi ) nuclear factor-kappa B activation ; and ( vii ) apoptosis ( terminal deoxynucleotidyltransferase mediated UTP end labeling staining, FAS ligand, Bax, and Bcl-2 expression )