Gene interactions and pathways from curated databases and text-mining

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E2F1 — PIK3R1

Text-mined interactions from Literome

Schild et al., Mol Carcinog 2009 (Carcinoma, Pancreatic Ductal...) : In this study we demonstrate that PI3K signaling controls transcription of the E2F1 gene and show that E2F1 is essential for S-phase progression of PDAC cells
Bhattacharya et al., Cancer Biol Ther 2012 (Stomach Neoplasms) : Here, we tested the hypothesis that the dual PI3K/mTOR inhibitor, PI103, could synergize with the chemotherapeutic agent, 5-fluorouracil ( 5-FU ) by inhibiting E2F1 , thymidylate synthase ( TS ) and enhancing DNA damage