Schild et al., Mol Carcinog 2009
(Carcinoma, Pancreatic Ductal...) :
In this study we demonstrate that PI3K signaling controls transcription of the E2F1 gene and show that E2F1 is essential for S-phase progression of PDAC cells
Bhattacharya et al., Cancer Biol Ther 2012
(Stomach Neoplasms) :
Here, we tested the hypothesis that the dual PI3K/mTOR inhibitor, PI103, could synergize with the chemotherapeutic agent, 5-fluorouracil ( 5-FU ) by inhibiting E2F1 , thymidylate synthase ( TS ) and enhancing DNA damage