Gene interactions and pathways from curated databases and text-mining

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E2F5 — RAC3

Text-mined interactions from Literome

Gille et al., J Biol Chem 1999 : Activated PI 3-kinase induces cyclin D(1) transcription and E2F activity, at least in part mediated by the serine/threonine kinase Akt/PKB, and to a lesser extent the Rho family GTPase Rac
Gjoerup et al., J Biol Chem 1998 (Genetic Predisposition to Disease) : The inhibitory effect of the cyclin dependent kinase inhibitors, p16(ink4), p21 ( cip1 ), and p27 ( cip ) on Rac/Cdc42 mediated E2F transcription corroborates a role for pRB family members and their functional inactivation by cyclin dependent kinases in generating E2F activity ... While the up-regulation of E2F transcriptional activity by Rac or Cdc42, not Rho, suffices for entry into S phase and DNA synthesis in Rat-1 R12 cells, this is clearly not the case in NIH 3T3, where additional requirements must exist