Gene interactions and pathways from curated databases and text-mining

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E2F8 — IFI27

Text-mined interactions from Literome

Rivard et al., Am J Physiol 1999 : In both cell types, expression of ras resulted in an increase of basal and serum stimulated E2F dependent transcriptional activity and a reduction in p27 ( Kip1 ) protein levels as well
Alexander et al., Mol Cell Biol 2001 : In addition, the use of pRb proteins mutated in the pocket domain demonstrates that pRb upregulation of p27 ( KIP1 ) and senescence induction do not require the interaction of pRb with E2F
Yuan et al., Cancer Res 2007 (Breast Neoplasms...) : In sum, loss of p27 activated AIB1, E2F1 , Gab2, and Akt ; increased cell migration and invasion ; caused antiestrogen insensitivity ; and promoted metastasis of breast cancer cells