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ECM1 — IL7

Text-mined interactions from Literome

Yamanaka et al., Curr Eye Res 2006 : We examined the role of interleukin-7 (IL-7) in modulation of production of extracellular matrix ( ECM ) , immunolocalization of Smads, and cell migration and expressions of transforming growth factor-beta ( TGF-beta ) in cultured human subconjunctival fibroblasts ... The effects of IL-7 on ECM production, immunolocalization of Smads, type I collagen, fibronectin, alpha -smooth muscle actin ( alpha -SMA ), and cell migration were examined in human subconjunctival fibroblast culture with or without TGF-beta1 ... IL-7 reduced the ECM production much more markedly in the cells treated with TGF-1beta than in the control fibroblasts ... These findings indicate that IL-7 is involved in ECM production in the subconjunctival fibroblasts activated by exogenous TGF-beta1, suggesting that administration of IL-7 can be a novel therapeutic strategy in preventing undesirable bleb scar formation during healing after filtration surgery
Sarkissian et al., J Rheumatol 1998 (Arthritis, Rheumatoid...) : Transforming growth factor-beta ( TGF-beta ) or platelet derived growth factor ( PDGF ), but not interleukin 1 or exogenous fibronectin, induced ECM fibronectin