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EDN2 — GPI

Text-mined interactions from Literome

Pinelis et al., Biull Eksp Biol Med 1992 : The treatments of VSMC with H-7 and staurosporine ( PK-C ) inhibitors prevented the pHi response to endothelin and PMA
Katoh et al., Res Commun Chem Pathol Pharmacol 1991 (Hypertension) : We evaluated the effect of aging on spontaneous release of prostaglandin I2 ( PGI2 ; measured as 6-keto-PGF1a ) as well as on endothelin induced release of PGI2 from isolated hind legs perfused with Krebs-Ringer solution in 5-week-old, 10-week-old and 40-week-old Wistar-Kyoto rats ( WKY ) and age matched spontaneously hypertensive rats ( SHR ) ... These results not only suggest that there exists a much greater reservoir of vascular PGI2 synthesis in SHR, but also imply that the enhanced release of PGI2 in response to endothelin , the most potent vasoconstrictor known, may function as a factor or a modulator to attenuate endothelin induced vasoconstriction in senescent SHR
Krämer et al., Circ Res 1991 (Alkalosis) : In isolated adult rat ventricular cells loaded with the H ( + ) -selective fluorescent probe BCECF, 100 pM endothelin increased contractile amplitude to 190 +/- 26 % of baseline and pHi by 0.08 +/- 0.02 ( n = 8 ), whereas 1 nM endothelin increased pHi by 0.13 +/- 0.03 with little further increase in contractility ... Amiloride ( 10 ( -4 ) M ) prevented the increase in pHi in response to endothelin and reduced the inotropic response by 45 %, although the inotropic effect could be readily restored by subsequent NH4Cl induced alkalinization
Touyz et al., Thromb Res 1995 : In order to determine whether this effect is mediated via protein kinase C and Na ( + ) -H+ linked pathways, the effects of staurosporine and calphostin C ( protein kinase C inhibitors ) and 5- ( N, N-hexamethylene ) amiloride ( Na ( + ) -H+ exchange blocker ) on endothelin induced pHi responses in human platelets were assessed