Smith et al., American journal of physiology. Renal physiology 2009
:
Quantitative RT-PCR and a luciferase reporter assay suggested that sHB-EGF repressed transcription of E-cadherin , and a concomitant TGF-beta independent upregulation of the E-cadherin repressor Snail-2 was observed
Cheng et al., Oncogene 2013
(Ovarian Neoplasms) :
These two signaling pathways contribute to the EGF induced downregulation of E-cadherin , which subsequently increases the invasive capability of ovarian cancer cells
Cheng et al., J Clin Endocrinol Metab 2012
:
Moreover, the inhibition of EGF induced ERK1/2, p38, and Akt activation by pharmacological inhibitors attenuated EGF induced Slug expression and the down-regulation of E-cadherin , as well as subsequent cell invasion