Gene interactions and pathways from curated databases and text-mining

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EGF — GPI

Text-mined interactions from Literome

Krishnamurthy et al., Prostaglandins Other Lipid Mediat 1999 : Although VEGF produced a similar response, EGF did not increase PGI2 production in UA ... In tPA, VEGF did not increase PGI2 production ; however, 10, 50, and 100 ng/mL EGF , enhanced ( p < 0.03 ) PGI2 production from 1.98 +/- 0.14 to 3.39 +/- 0.62, 3.62 +/- 0.26, and 2.93 +/- 0.20 ... We conclude that PGI2 production is augmented by bFGF in UA, pPA and tPA, by VEGF in UA, and by EGF in tPA during ovine pregnancy
Yanaka et al., Am J Physiol Gastrointest Liver Physiol 2002 : At neutral luminal pH, exogenous EGF ( ex-EGF ) increased pH(i) and enhanced restitution in the absence but not in the presence of serosal HCO
Hasegawa et al., Mech Ageing Dev 1992 : Therefore, EGF does not suppress the age related decrease ( in vitro senescence ) in the ability of cultured HUVE cells to produce PGI2
Li et al., Endocrinology 1991 : EGF ( 5-100 ng/ml ) induced a concentration dependent increase in pHi , which reached a maximum of 0.217 +/- 0.009 pH units at a concentration of 100 ng/ml EGF
Takasu et al., Biochem Biophys Res Commun 1988 : Using cultured porcine thyroid cells, we studied the effects of epidermal growth factor (EGF) on pHi and [ 3H ] thymidine incorporation ; 10 nM EGF alkalinizes thyroid cells and stimulates thymidine incorporation
Ober et al., J Cell Physiol 1987 : Furthermore, exposure of cells to the phorbol ester PMA for a prolonged period of time in order to down-regulate protein kinase C ( pkC ), or treatment with the pkC inhibitor H-7, abolished the pHi response to thrombin but not to EGF
Stanton et al., Am J Physiol 1988 : We have studied the role of EGF in the growth of rat renal proximal tubule ( PT ) cells in primary culture and monitored the early effects of EGF on pHi in these cells using microfluorimetry and the pHi probe, 2',7'-biscarboxyethyl-5 ( 6 ) -carboxyfluorescein ( BCECF )
Ristimäki et al., Thromb Haemost 1988 : This effect of EGF was dose dependent, the lowest stimulatory concentration of EGF was 1.0 ng/ml and 100 ng/ml caused a 2.7 +/- 0.3 ( mean +/- SEM ) fold increase in the PGI2 synthesis
Yada et al., Osaka City Med J 1994 (Carcinoma, Hepatocellular...) : However, non regenerating hepatocytes displayed little increase, regenerating hepatocytes displayed substantial increase in DNA synthesis with increasing pHi in the presence of EGF or HGF
Braconi Quintaje et al., J Mol Cell Cardiol 1998 : The tyrosine kinase inhibitors lavendustin ( 1 microM ) and genistein ( 10 microM ) strongly inhibited EGF induced MAPK activation and PGI2-formation , but had no effect on PMA stimulated responses