◀ Back to PIK3R1
EGFR — PIK3R1
Pathways - manually collected, often from reviews:
-
BioCarta egf signaling pathway:
EGF/EGF-R complex (EGF-EGFR)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, activates)
-
KEGG Focal adhesion:
EGFR/ERBB2/FLT1/FLT4/IGF1R/KDR/MET/PDGFRA/PDGFRB
→
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
(protein-protein, activation)
-
KEGG Pathways in cancer:
EGFR
→
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
(protein-protein, activation)
-
KEGG Pancreatic cancer:
Complex of EGFR-ERBB2
→
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
(protein-protein, indirect effect)
-
KEGG Endometrial cancer:
EGFR
→
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
(protein-protein, activation)
-
KEGG Glioma:
EGFR
→
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
(protein-protein, activation)
-
KEGG Glioma:
EGFR
→
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
(protein-protein, activation)
-
KEGG Prostate cancer:
EGFR/ERBB2/FGFR1/FGFR2/IGF1R/INSRR/PDGFRA/PDGFRB
→
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
(protein-protein, activation)
-
NCI Pathway Database LPA receptor mediated events:
Gab1 (GAB1)
→
EGFR/PI3K-beta/Gab1 complex (PIK3CB-PIK3R1-EGFR-GAB1)
(modification, collaborate)
Laffargue et al., J Biol Chem 1999
Evidence: mutant phenotype, assay
-
NCI Pathway Database LPA receptor mediated events:
EGFR/PI3K-beta/Gab1 complex (PIK3CB-PIK3R1-EGFR-GAB1)
→
EGFR (EGFR)
(modification, collaborate)
Laffargue et al., J Biol Chem 1999
Evidence: mutant phenotype, assay
-
NCI Pathway Database LPA receptor mediated events:
EGFR/PI3K-beta/Gab1 complex (PIK3CB-PIK3R1-EGFR-GAB1)
→
PI3K-beta complex (PIK3CB-PIK3R1)
(modification, collaborate)
Laffargue et al., J Biol Chem 1999
Evidence: mutant phenotype, assay
-
NCI Pathway Database LPA receptor mediated events:
EGFR (EGFR)
→
PI3K-beta complex (PIK3CB-PIK3R1)
(modification, collaborate)
Laffargue et al., J Biol Chem 1999
Evidence: mutant phenotype, assay
-
NCI Pathway Database LPA receptor mediated events:
EGFR/PI3K-beta/Gab1 complex (PIK3CB-PIK3R1-EGFR-GAB1)
→
None
(modification, activates)
Laffargue et al., J Biol Chem 1999
Evidence: mutant phenotype, assay
-
NCI Pathway Database LPA receptor mediated events:
EGFR/PI3K-beta/Gab1 complex (PIK3CB-PIK3R1-EGFR-GAB1)
(modification, activates)
Laffargue et al., J Biol Chem 1999
Evidence: mutant phenotype, assay
-
Reactome Reaction:
EGFR
→
PIK3R1
(indirect_complex)
Rodrigues et al., Mol Cell Biol 2000, Jackson et al., Cancer Res 2004, Lynch et al., N Engl J Med 2004, Sordella et al., Science 2004, Pao et al., Proc Natl Acad Sci U S A 2004, Greulich et al., PLoS Med 2005, Yang et al., Cancer Res 2006, Choi et al., Oncogene 2007, Lee et al., PLoS Med 2006, Huang et al., Proc Natl Acad Sci U S A 2007, Xu et al., Br J Cancer 2007, Holgado-Madruga et al., Proc Natl Acad Sci U S A 1997
-
Reactome Reaction:
EGFR
→
PIK3R1
(reaction)
Jackson et al., Cancer Res 2004, Lynch et al., N Engl J Med 2004, Sordella et al., Science 2004, Pao et al., Proc Natl Acad Sci U S A 2004, Greulich et al., PLoS Med 2005, Yang et al., Cancer Res 2006, Choi et al., Oncogene 2007, Lee et al., PLoS Med 2006, Huang et al., Proc Natl Acad Sci U S A 2007, Xu et al., Br J Cancer 2007, Holgado-Madruga et al., Proc Natl Acad Sci U S A 1997
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
EGFR
—
PIK3R1
McGlade et al., Mol Cell Biol 1992*
-
IRef Bind_translation Interaction:
EGFR
—
PIK3R1
(far western blotting)
McGlade et al., Mol Cell Biol 1992*
-
IRef Biogrid Interaction:
EGFR
—
PIK3R1
(physical association, affinity chromatography technology)
Wen et al., Int J Oncol 2011*
-
IRef Biogrid Interaction:
EGFR
—
PIK3R1
(direct interaction, unspecified method)
Jones et al., Nature 2006
-
IRef Biogrid Interaction:
EGFR
—
PIK3R1
(physical association, affinity chromatography technology)
Fukazawa et al., J Biol Chem 1996
-
IRef Biogrid Interaction:
EGFR
—
PIK3R1
(physical association, affinity chromatography technology)
Tong et al., Mol Cell Proteomics 2009
-
IRef Hprd Interaction:
EGFR
—
PIK3R1
(in vivo)
Fukazawa et al., J Biol Chem 1996
-
IRef Intact Interaction:
EGFR
—
PIK3R1
(association, competition binding)
Stover et al., J Biol Chem 1995*
-
IRef Intact Interaction:
EGFR
—
PIK3R1
(physical association, coimmunoprecipitation)
Fukazawa et al., J Biol Chem 1996
-
IRef Intact Interaction:
EGFR
—
PIK3R1
(direct interaction, protein array)
Jones et al., Nature 2006
-
IRef Intact Interaction:
Complex of 29 proteins
(association, tandem affinity purification)
Li et al., Molecular systems biology 2013
-
IRef Intact Interaction:
Complex of 40 proteins
(association, tandem affinity purification)
Li et al., Molecular systems biology 2013
-
IRef Intact Interaction:
Complex of 13 proteins
(association, pull down)
Wang et al., Cancer Cell 2006
-
IRef Intact Interaction:
Complex of PIK3R1-EGFR-PTPN11-GAB2-GRB2
(association, anti tag coimmunoprecipitation)
Brummer et al., J Biol Chem 2006*
-
IRef Intact Interaction:
Complex of PIK3R1-SHC1-ERBB2-ERBB3-EGFR
(association, pull down)
Wang et al., Cancer Cell 2006
-
IRef Ophid Interaction:
EGFR
—
PIK3R1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
-
IRef Ophid Interaction:
EGFR
—
PIK3R1
(aggregation, confirmational text mining)
Jones et al., Nature 2006
Text-mined interactions from Literome
Ram et al., J Cell Physiol 2000
(Breast Neoplasms) :
Furthermore, erbB-3 principally mediated the direct recruitment of p85 in cells stimulated by HRG or EGF, indicating that, in addition to the high-level activation of PI3K by p185(erbB-2) / erbB-3,
EGFR/erbB-3 heterodimer interaction is
essential for the weak but significant level of
PI3K activated by EGF in cells that express normal EGFR levels
Wu et al., Oncogene 2000
(Brain Neoplasms...) :
These data reveal a pathway that negatively regulates
EGFR induced
PI3-K activation in glioblastoma cells and involves interactions between SHP2 and tyrosine phosphorylated SIRPalpha1
von Lindern et al., Oncogene 2001
(Cell Transformation, Neoplastic...) :
However, while v-ErbB transformed cells and normal progenitors depended on
PI3K signaling for renewal,
c-ErbB also
induces progenitor expansion by PI3K independent mechanisms
Viñals et al., Mol Cell Biol 2001
:
We established that TGF-beta1 stimulated the expression of TGF-alpha mRNA and protein, the tyrosine phosphorylation of a 170-kDa membrane protein representing the
epidermal growth factor (EGF) receptor , and the delayed
activation of
PI3K/Akt and p42/p44 MAPK
Thomas et al., J Biol Chem 2002
(Calcium Signaling) :
Together, these data indicate that H ( 2 ) O ( 2 ) promotes calcium dependent eNOS activity through a coordinated change in the phosphorylation status of the enzyme mediated by Src- and
ErbB receptor
dependent PI 3-K activation
Chakravarti et al., Cancer Res 2002
(Brain Neoplasms...) :
It was found that BCNU inhibited radiation induced apoptosis through
EGFR mediated
activation of
PI3-K/AKT via RAS
Arboleda et al., Cancer Res 2003
(Breast Neoplasms...) :
Furthermore, expression of kinase dead AKT2 ( 181 amino acid methionine [ M ] ), and not kinase dead AKT1 ( 179M ) or AKT3 ( 177M ), was capable of blocking invasion induced by either human
epidermal growth factor receptor-2 ( HER-2 ) overexpression or by
activation of
PI3-K
Zhuang et al., American journal of physiology. Renal physiology 2004
:
These results show that
EGFR activation is required for RPTC proliferation and migration and that proliferation is
mediated by
PI3K , whereas migration is mediated by p38
Nicholl et al., J Vasc Surg 2005
:
uPA activation of
PI3K and MKK3/6 was
EGFR dependent and that of MEK1 was EGFR independent
Shah et al., J Cell Physiol 2006
(MAP Kinase Signaling System) :
However, the extent to which
EGF-R transactivation is
essential for GPCR agonist stimulated
PI3K activation is not known ... In C9 hepatocytes, agonist activation of AT1 angiotensin II ( AT1-R ), lysophosphatidic acid (LPA), and EGF receptors caused phosphorylation of Akt through activation of the
EGF-R in a
PI3K dependent manner
Ihle et al., Mol Cancer Ther 2005
(Carcinoma, Non-Small-Cell Lung...) :
Recent work shows that phosphatidylinositol-3-kinase (PI3-K) is coupled to the EGFR only in NSCLC cell lines expressing ErbB-3 and that
EGFR inhibitors do not
inhibit PI3-K signaling in these cells
Zhang et al., J Biol Chem 2006
:
In this study we investigated a potential link between the
PI3K-Akt pathway and the cigarette smoke ( CS ) -stimulated
epidermal growth factor receptor mediated FRA-1
induction in non-oncogenic HBE cells
Zhan et al., Cancer Res 2006
(Breast Neoplasms...) :
The ability of heterodimers to induce invasion required the
ErbB1 kinase activity and
required activation of
PI3K , Ras/mitogen activated protein kinase, and phospholipase Cgamma1 signaling pathways
Kolb et al., Int J Cancer 2007
(Pancreatic Neoplasms) :
HRGs induced phosphorylation of different
ErbB receptors as well as
activation of MAPK, p38MAPK, JNK and
PI3K in a cell- and ligand-specific manner
Tétreault et al., J Cell Physiol 2008
:
Epidermal growth factor receptor dependent
PI3K-activation promotes restitution of wounded human gastric epithelial monolayers ... In conclusion, the present results indicate that
EGFR dependent
PI3K activation promotes restitution of wounded human gastric epithelial monolayers
Nie et al., Mech Dev 2007
:
PI3K and Erk MAPK
mediate ErbB signaling in Xenopus gastrulation
Liu et al., Pathophysiology : the official journal of the International Society for Pathophysiology / ISP 2007
:
Work with genetic manipulations, as well as pharmacological agents with cell culture models, have demonstrated that the cardiotonic steroid stimulated endocytosis of the plasmalemmal Na/K-ATPase requires caveolin and clathrin as well as the activation of c-Src, transactivation of the
EGFR and
activation of
PI3K
Raufman et al., J Cell Physiol 2008
(Colonic Neoplasms) :
Deoxycholyltaurine rescues human colon cancer cells from apoptosis by activating
EGFR dependent
PI3K/Akt signaling
Lin et al., Toxicol Appl Pharmacol 2008
:
LPS stimulated Src, PYK2,
EGFR , and Akt phosphorylation and VCAM-1 expression were
attenuated by the inhibitors of Src ( PP1 ), EGFR ( AG1478 ),
PI3-K ( LY294002 and wortmannin ), and Akt ( SH-5 ), respectively, or transfection with siRNAs of Src or Akt and shRNA of p110
Cao et al., Cell Signal 2008
:
Inhibition of
EGFR also
suppresses UV-induced activation of
PI3K/AKT/mTOR/S6K and NF-kappaB signal transduction pathways
Tabassam et al., Cell Microbiol 2009
:
Pharmacologic inhibitors of PI3K or mitogen activated protein kinase kinase ( MEK ), Akt knock-down and EGFR knock-down showed that H. pylori infection induced the
activation of
EGFR -- >
PI3K -- > PI3K dependent kinase 1 -- > Akt -- > extracellular signal regulated kinase signalling pathways, the inactivation of glycogen synthase kinase 3beta and interleukin-8 production
Nagy et al., J Infect Dis 2009
:
H. pylori enhanced
PI3K-AKT signaling in a Src- and
epidermal growth factor receptor dependent manner, which was also mediated by a functional cag secretion system and peptidoglycan
Wheeler et al., Cancer Biol Ther 2009
(Carcinoma, Non-Small-Cell Lung...) :
We now present data that Src family kinases (SFKs) are highly activated in cetuximab-resistant cells and enhance
EGFR activation of HER3 and
PI(3)K/Akt
Yin et al., Invest Ophthalmol Vis Sci 2010
:
LL-37 enhanced the closure of a scratch wound in cultured HCECs and partially rescued HG-attenuated wound healing in an EGFR- and a
PI3K dependent manner and restored HG-impaired
EGFR signaling in cultured porcine corneas
Bai et al., Life Sci 2010
(Carcinoma, Hepatocellular...) :
The phosphorylation of
EGFR and Akt were elevated in EP1 agonist treated cells, and both EGFR and
PI3K inhibitors
suppressed the upregulation of survivin induced by PGE ( 2 ) or EP1 agonist
Su et al., Life Sci 2010
(Adenocarcinoma...) :
Immunoblot showed that NFD inhibited
EGFR phosphorylation and the
activation of
PI3K/Akt , downstream molecules of EGFR pathway, in A549 cells
Krishnaswamy et al., Endocrinology 2010
:
Thus,
EGFR may simultaneously
activate c-Src and
PI3K to amplify the OT signaling to increase the output of PGF ( 2 alpha ) in bEEL cells
Zuo et al., Breast Cancer Res 2010
(Breast Neoplasms...) :
To define the potential inter-mediate steps between mPRalpha and PI3K, we demonstrated that mPRalpha, caveolin-1 (Cav-1), and
epidermal growth factor receptor (EGFR) are colocalized in the membrane of caveolar vesicle and the P4-repressed EMT in MB468 cells can be
blocked by EGFR inhibitor ( AG1478 ) and
PI3K inhibitor ( wortmannin )
Wakasaki et al., Neoplasia (New York, N.Y.) 2010
(Carcinoma, Squamous Cell...) :
Little is known, however, about a
role of
CIN85 in
EGFR signaling as well as its relevance to tumor development and progression of HNSCC
He et al., Ann Oncol 2012
(Breast Neoplasms...) :
Human
epidermal growth factor receptor ( HER2 ), insulin receptor and IGF-I receptor
involve the same
PI3K/AKT/mTOR signaling, and different antidiabetic pharmacotherapy may differentially affect this pathway, leading to different prognoses of HER2+ breast cancer
Meira et al., Molecular cancer 2011
:
The combination of PD98059 and matuzumab did not show the same effect suggesting that
PI3K is an important
effector of
EGFR signaling in matuzumab treated cells
Zhao et al., J Lipid Res 2012
:
Further studies showed that TNF-a decreased expression of the antiapoptotic proteins Bcl-2 and Bcl-xL, decreased I?Ba and PPAR?, and also inhibited
PI3K dependent Akt and
EGFR signaling
Tajeddine et al., J Biol Chem 2012
(MAP Kinase Signaling System) :
This was associated with a decreased phosphorylation and
activation of
EGFR and with a subsequent disruption of
PI3K/Akt and MAPK downstream pathways
Tsai et al., Toxicon 2012
(MAP Kinase Signaling System...) :
These findings suggest that CTX III inhibited the EGF induced invasion and migration of MDA-MB-231 cells via
EGFR dependent
PI3K/Akt , ERK1/2, and NF-?B signaling, leading to the down-regulation of MMP-9 expression
Tabara et al., PloS one 2012
(Lung Neoplasms) :
However, constitutive
activation of
EGFR downstream signaling,
PI3K/Akt , was observed even after loss of the mutated EGFR gene in all resistant cell lines even in the presence of the drug
Schroeder et al., Mol Biol Cell 2012
:
In this study we show that
EGFR activation
leads to a pronounced src mediated tyrosine phosphorylation of
CIN85 that subsequently influences EGFR ubiquitination
Hsieh et al., Toxicol In Vitro 2013
(Breast Neoplasms...) :
These findings suggest that NFD inhibited the EGF induced invasion and migration of MDA-MB-231 cells via
EGFR dependent
PI3K/Akt signaling, leading to the down-regulation of MMP-9 expression