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EGFR — PRKAR1B
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Barbier et al., J Biol Chem 1999
:
Because cAMP activates the cAMP dependent protein kinase A (PKA), we investigated the
effect of
PKA on the
EGFR
Piiper et al., Biochem Biophys Res Commun 2003
:
Chemical inhibition of
PKA suppressed forskolin induced
EGFR tyrosine phosphorylation and ERK1/2 activation in PC12 cells ... Together, our data indicate that activation of
PKA mediates the effects of cAMP on the
EGFR and ERK1/2 ... While PKA may directly phosphorylate the EGFR on serine residues,
PKA induced tyrosine phosphorylation of the
EGFR occurs by an indirect mechanism
Galdiero et al., J Infect 2003
:
The inhibitors of PTK, PKA and PKC activation used, were : 3,4-dihydroxybenzylidene-malononitrile ( tyrphostin 23 ), inhibitor of
epidermal growth factor (EGF) receptor tyrosine kinase activity ; dihychloride ( H-89 ), a selective
inhibitor of
PKA which is useful to discriminate between the effects of PKC and PKA ; diacylglycerol kinase inhibitor II ( R59949 ), which is useful for elucidating roles of PKC ; calphostin C, a specific inhibitor of PKC
Tortora et al., Clin Cancer Res 2003
(Neovascularization, Pathologic) :
COX-2 expression can be induced by
EGFR activation and is
regulated by cAMP and
PKA
Reinehr et al., Gastroenterology 2004
:
Inhibition of bile salt induced apoptosis by cAMP involves both
PKA dependent Ser/Thr phosphorylation of the CD95 and
inhibition of
EGF-R activation, which results in an inhibition of CD95 tyrosine phosphorylation, CD95 membrane targeting, and DISC formation
Monje et al., J Biol Chem 2008
:
The
role of
PKA in
neuregulin-ErbB signaling was confirmed using PKA inhibitors, pathway-selective cAMP analogs, and natural ligands stimulating PKA activity in SCs, such as adenosine and epinephrine
Daniel et al., Dev Biol 2010
:
Moreover, we show here that
PKA and SRC family are
involved in the activation of
EGFR by 10 microM ouabain, further demonstrating that ouabain induces the acrosome reaction by a mechanism mediated by the trans-activation of EGFR
Breitbart et al., Asian J Androl 2011
:
In the capacitation process, the
EGFR is partially
activated by
protein kinase A (PKA) , resulting in phospholipase D ( PLD ) activation and actin polymerization ... Under in vivo conditions, the
EGFR can be directly
activated by its known ligand epidermal growth factor (EGF), and indirectly by activating
PKA or by transactivation mediated by G protein coupled receptors ( GPCRs ) activation or by ouabain
Fishman et al., Cancer Res 1997
(Fibrosarcoma...) :
Most importantly, our experiments have demonstrated the existence of a novel character of interactions between EGFR and PKA, because the ligation of the
EGFR by epidermal growth factor in the metastatic variant
induced a high activity of
PKA