Gene interactions and pathways from curated databases and text-mining

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EGR1 — PIK3R1

Text-mined interactions from Literome

Guillemot et al., J Biol Chem 2001 (MAP Kinase Signaling System) : Taken together, these findings demonstrate that Ang II-induced cyclin D1 up-regulation is mediated by the activation and specific interaction of Egr-1 with the -136 to -96 bp region of the cyclin D1 promoter and by activation of the -29 to +139 bp region, both in a p21(ras)/Raf-1/MEK/ERK dependent manner, and also involves PI3K and SHP-2
Fujino et al., J Biol Chem 2003 (MAP Kinase Signaling System) : Furthermore, this activation of PI3K/ERK signaling by the EP ( 4 ) receptors induces the functional expression of early growth response factor-1 (EGR-1)
Shin et al., EMBO J 2006 : Inhibition of PI3K signaling restored the downregulation of SRF and Egr-1 expression caused by oncogenic Ras