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EIF4EBP1 — PIK3R1
Text-mined interactions from Literome
Pham et al., Circ Res 2000
:
One mechanism involves
PI3K/PKB dependent phosphorylation of
4E-BP1 , which dissociates from eIF4E, allowing initiation of translation from the 7-methylGTP cap of mRNAs
Shi et al., J Biol Chem 2002
(MAP Kinase Signaling System...) :
These results indicate that both ERK and PI3-K/AKT pathways are required for optimal IL-6 induced p70 activity, but
PI3-K/AKT is
sufficient for
4E-BP1 phosphorylation
Nawroth et al., PloS one 2011
(Carcinoma, Transitional Cell...) :
Instead, we provide evidence for an alternative mTOR independent but
PI3K dependent regulation of
4E-BP1
Fischer et al., Lung Cancer 2012
(Mesothelioma...) :
The
PI3K/mTOR inhibitor NVP-BEZ235 and PI3K inhibitor wortmannin
reduced the phosphorylation of downstream target AKT, S6 and
4EBP1 and decreased the SP fraction
Polakiewicz et al., J Biol Chem 1998
:
Phosphorylation of p70 S6 kinase and
4E-BP1 is also
repressed by
PI3K inhibitors as well as by rapamycin, the selective inhibitor of FRAP/mTOR